EVALUATION OF THE EFFECTIVENESS OF COMPLEX TREATMENT OF BLEPHARITIS USING PHOTODYNAMIC THERAPY

Purpose:  To optimize methods of comprehensive treatment of blepharitis using photodynamic therapy (PDT).

Materials and methods. The study involved 80 patients, who were randomly assigned into two groups: a control group and a main group. Participants in the control group underwent conventional therapeutic measures, including hygienic cleansing of the eyelid margins with a 0,02% furacilin solution and topical application of 1% tetracycline ointment. In the main group, along with standard therapy, photodynamic therapy (PDT) was additionally used.

Results and discussions. Integration of photodynamic therapy into the treatment protocol significantly accelerated the resolution of the inflammatory process. By the third day of treatment, the inflammation index had decreased by 2,92 times, and by the eighth day, all patients in the main group exhibited complete regression of eyelid inflammation. Clinical manifestations such as eyelid swelling and hyperemia showed a notable reduction within 4–5 days in the PDT group, whereas in the control group these symptoms subsided only by day 6. Furthermore, pathogenic microflora was eliminated in 85.4% of patients in the main group within 4–5 days, while in the control group complete microbial clearance was achieved only after 6–7 days.

Conclusions. The inclusion of photodynamic therapy in complex treatment increases the effectiveness of blepharitis therapy. PDT ensures faster elimination of inflammatory signs, promotes eradication of pathogenic microflora in 85,4% of cases, and reduces the duration of treatment by an average of 5–6 days.

1. Filatova N.V. Fotodinamicheskaya terapiya v lechenii neovaskulyarizatsii rogovitsy u detei (Photodynamic therapy in the treatment of corneal neovascularization in children): avtoref. dis. … kand. med. nauk.. Moscow, 2012: 26. (In Russ).]

2. Chekhova T.A., Chernykh V.V. Ophthalmic rosacea: etiology, pathogenesis, new approaches to therapy. Ophthalmic Surgery. 2016; 2:54-58. (In Russ).] http://dx.doi.org/10.25276/0235-4160-2016-2-54-59

3. Shurubey V.A., Teplyuk N.P., Smirennaya E.V. Clinical manifestations and treatment of blepharitis and dry eye syndrome in rosacea. Cataract and Refractive Surgery. 2014,14(2):38-44. (In Russ). https://doi.org/10.25276/2410-1257-2023-2-62-65

4. Bakhtitdinova F.A., Narzikulova K.I., Mirrakhimova S. Sh., A. Khera. Effectiveness of Photodynamic Therapy in the Healing of Corneal Alkali Burn in Rats // International Journal of Biomedicine. – USA. New York, 2016. – №6(2). – P. 124–127. https://doi:10.21103/Article6(2)_OA6

5. Narzikulova K.I. Оценка эффективности комплексного лечения воспалительных заболеваний глазной поверхности с применением фотодинамической терапии // Научно-практический журнал «Восток-Запад. Точка зрения». – Россия. Уфа, 2017. – №3. – С. 67–69.

6. Almeida, A. Photodynamic therapy in the inactivation of microorganisms. Antibiotics. – 2020.9.138. [Almeida, A. Photodynamic therapy in the inactivation of microorganisms. Antibiotics. 2020.9.138.] https://doi.org/10.3390/antibiotics9040138

7. Ha, M. J. Song, S. Park, K. Han, H.S. Hwang, H.S. Kim, R. Arita, K.S. Na Relationship between serum lipid level and meibomian gland dysfunction subtype in Korea using propensity score matching. Scientific Reports. –2021.9, 11(1) –P.16102. [Ha, M. J. Song, S. Park, K. Han, H.S. Hwang, H.S. Kim, R. Arita, K.S. Na Relationship between serum lipid level and meibomian gland dysfunction subtype in Korea using propensity score matching. Scientific Reports. –2021.l.9,11(1) .16102.] https://doi:10.1038/s41598-021-95599-y.

8. Lapp, T. P. Maier, T. Jakob, T. Reinhard Pathophysiology of atopic blepharokeratoconjunctivitis. Ophthalmologe. – 2017.114(6).504-513. [Lapp, T. P. Maier, T. Jakob, T. Reinhard Pathophysiology of atopic blepharokeratoconjunctivitis. Ophthalmologe. – 2017 .114(6).504-513] https://doi:10.1007/s00347-017-0483-1

9. Lu, L.J. L.JLu Human Microbiota and Ophthalmic Disease Yale Journal of Biology and Medicine. – 2016.30;89(3).325-330. [Lu, L.J. L.JLu Human Microbiota and Ophthalmic Disease Yale Journal of Biology and Medicine. – 2016 Sep. – №30;89(3) –P.325-330 ] https://doi.org/10.25276/2410-1257-2023-2-62–65

10. Zhao, X. J. Liu, J. Fan, H. Chao, X. Peng, Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: From molecular design to application. Chem. Soc. Rev. – 2021..50.4185–4219. [Zhao, X. J. Liu, J. Fan, H. Chao, X. Peng Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: From molecular design to application. Chem. Soc. Rev. – 2021.50.4185–4219.] https://doi:10.1039/D0CS00173B