pirogovestnikВестник Национального медико-хирургического центра им. Н.И. ПироговаBulletin of Pirogov National Medical & Surgical Center2072-82552782-3628Национальный медико-хирургический Центр им. Н.И. Пирогова10.25881/20728255_2026_21_3_124pirogovestnik-663Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWSДИАГНОСТИКА РАКА ОКОЛОЩИТОВИДНОЙ ЖЕЛЕЗЫ: ИНСТРУМЕНТАЛЬНЫЕ МЕТОДЫ И ПЕРСПЕКТИВЫ АНАЛИЗА МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИХ БИОМАРКЕРОВDIAGNOSIS OF PARATHYROID CARCINOMA: INSTRUMENTAL METHODS AND PROSPECTS FOR MOLECULAR AND GENETIC BIOMARKERS ANALYSISЖивотовВ. А.ZhivotovV. A.

Москва

Moscow

ПавловН. П.PavlovN. P.

Москва

Moscow

pavlovnp@pirogov-center.ruДжайнМ.JainM.

Москва

Moscow

ФГБУ «Национальный медико-хирургический Центр им. Н.И. Пирогова»РоссияPirogov National Medical and Surgical CenterRussian FederationУниверситетская клиника Медицинского научно-образовательного института МГУ им. М.В. ЛомоносоваРоссияUniversity Clinic Medical Research and Educational Institute Lomonosov Moscow State UniversityRussian Federation202603092026213124131Copyright © Животов В.А., Павлов Н.П., Джайн М., 20262026Животов В.А., Павлов Н.П., Джайн М.Zhivotov V.A., Pavlov N.P., Jain M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://submit.pirogov-vestnik.ru/jour/article/view/663

Рак околощитовидной железы (РОЩЖ) – это редкое злокачественное новообразование, на долю которого приходится менее 1% всех наблюдений первичного гиперпаратиреоза (ПГПТ). Выявляемость РОЩЖ на ранних стадиях неуклонно возрастает, вероятно, в силу расширенного скрининга уровня кальция в сыворотке крови. Хирургическое вмешательство является основным и единственным эффективным методом лечения как при первичной опухоли, при рецидивах и отдаленных метастазах, однако выбор объема первичной операции остается открытым. На сегодняшний день не существует специфических маркеров РОЩЖ. Вопрос установления диагноза РОЩЖ на дооперационном этапе остается нерешенным. Все большее значение придается топической диагностике данных образований, однако на практике все методы топической диагностики имеют свои ограничения, в частности ультразвуковая диагностика является крайне специалист-зависимой методикой. В данном обзоре представлены современные достижения в области предоперационной диагностики РОЩЖ, а также их преимущества и недостатки.

Parathyroid carcinoma (PC) is a rare malignant neoplasm that accounts for less than 1% of all cases of primary hyperparathyroidism (PHPT). The detection of early-stage PC is steadily increasing likely due to expanded screening of serum calcium levels. Surgical intervention is the primary and only effective treatment for primary tumor as well as for recurrent and metastatic PC. However, the optimal extent of the primary surgical procedures remains unclear. There are no specific biomarkers for PC currently. The issue of preoperative PC diagnosis remains unresolved. Topical diagnosis of these neoplasms is increasingly important, however, in practice such methods have certain limitations. In particular, ultrasound requires special training of specialists. This review presents current advances in preoperative diagnosis of PC and examines their advantages and limitations.

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The authors declare that there are no conflicts of interest present.