<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pirogovestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Национального медико-хирургического центра им. Н.И. Пирогова</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Pirogov National Medical &amp; Surgical Center</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8255</issn><issn pub-type="epub">2782-3628</issn><publisher><publisher-name>Национальный медико-хирургический Центр им. Н.И. Пирогова</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25881/20728255_2026_21_1_166</article-id><article-id custom-type="elpub" pub-id-type="custom">pirogovestnik-554</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>ЭФФЕКТИВНОСТЬ ВЫПОЛНЕНИЯ ЛИТОЛИТИЧЕСКОЙ ТЕРАПИИ У ПАЦИЕНТКИ С КРУПНЫМИ УРАТНЫМИ КОНКРЕМЕНТАМИ ВЕРХНИХ МОЧЕВЫВОДЯЩИХ ПУТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>EFFICIENCY OF PERFORMING LITHOLYTIC THERAPY IN A PATIENT WITH LARGE UPPER URINARY TRACT STONES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ханалиев</surname><given-names>Б. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Hanaliev</surname><given-names>B. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барсегян</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Barsegyan</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">barsegyanag@pirogov-center.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медико-хирургический Центр им. Н.И. Пирогова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov National Medical and Surgical Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>21</day><month>03</month><year>2026</year></pub-date><volume>21</volume><issue>1</issue><fpage>166</fpage><lpage>169</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ханалиев Б.В., Барсегян А.Г., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Ханалиев Б.В., Барсегян А.Г.</copyright-holder><copyright-holder xml:lang="en">Hanaliev B.V., Barsegyan A.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://submit.pirogov-vestnik.ru/jour/article/view/554">https://submit.pirogov-vestnik.ru/jour/article/view/554</self-uri><abstract><p>Представлено клиническое наблюдение консервативного лечения пациентки с крупным камнями правой почки, лоханочно-мочеточникового сегмента справа и обтекаемого конкремента нижней трети правого мочеточника. К особенностям проведения литолитической терапии у данной категории пациентов можно отнести высокую частоту низкой комплаентности, нарушение диеты, наличие нарушений эндокринной системы и высокую частоту рецидивов мочекаменной болезни, высокий риск развития приступов почечной колики.</p></abstract><trans-abstract xml:lang="en"><p>The article presents a clinical observation of patient with a large stone in the right ureteropelvic segment and a calculus in the lower third of the right ureter. The specific features of litholytic therapy in patients of this category include low compliance, diet violation, the patology of endocrine system and initial causes of recurrent urolithiasis, and a high risk of developing renal colic attacks.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мочекаменная болезнь</kwd><kwd>уратный нефролитиаз</kwd><kwd>камень мочеточника</kwd><kwd>камень лоханочно-мочеточникового сегмента</kwd><kwd>пероральный хемолиз</kwd><kwd>литолиз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>urolithiasis</kwd><kwd>uric acid nephrolithiasis</kwd><kwd>ureteral stone</kwd><kwd>ureteropelvic segment stone</kwd><kwd>oral chemolysis</kwd><kwd>litholysis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аполихин О.И., Сивков А.В., Москалева Н.Г., Солнцева Т.В., Комарова В.А. Анализ уронефрологической заболеваемости и смертности в Российской Федерации за десятилетний период (2008–2018 гг.) по данным официальной статистики // Экспериментальная и клиническая урология.– 2019.–№2.–С.2-12.</mixed-citation><mixed-citation xml:lang="en">Apolikhin OI, Sivkov AV, Moskaleva NG, Solntseva TV, Komarova VA. Analiz uronefrologicheskoi zabolevaemosti i smertnosti v Rossiiskoi Federatsii za desiatiletnii period (2008–2018 gg.) po dannym ofitsial’noi statistiki. Eksperimental’naia i klinicheskaia urologiia. 2019; 2: 2-12. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Досаева Л.А., Шатохина С.Н., Шилов Е.М. Диагностика, медикаментозное лечение и профилактика мочекаменной болезни // Клиническая медицина.–2017.–№1.– С.21-27.</mixed-citation><mixed-citation xml:lang="en">Dosaeva LA, Shatokhina SN, Shilov EM. Diagnostika, medikamentoznoe lechenie i profilaktika mochekamennoi bolezni. Klinicheskaia meditsina. 2017; 1: 21-27. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Земченков А.Ю., Томилина Н.А. K/DOQI обращается к истокам хронической почечной недостаточности (о новом разделе Рекомендаций K/DOQI по диагностике, классификации и оценке тяжести хронических заболеваний почек) // Нефрология и диализ.–2016.–№6(3).–С.204-220.</mixed-citation><mixed-citation xml:lang="en">Zemchenkov AYu, Tomilina NA. K/DOQI obrashchaetsia k istokam khronicheskoi pochechnoi nedostatochnosti (o novom razdele Rekomendatsii K/DOQI po diagnostike, klassifikatsii i otsenke tiazhesti khronicheskikh zabolevanii pochek). Nefrologiia i dializ. 2016; 6(3): 204-220. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Knoll T, Shubert AB, Fahlenkamp D, et al. Urolithiasis through the ages: data on more than 200,000 urinary stone analyses. J Urol. 2011; 185(4): 1304-1311. doi: 10.1016/j.juro.2010.11.050.</mixed-citation><mixed-citation xml:lang="en">Knoll T, Shubert AB, Fahlenkamp D, et al. Urolithiasis through the ages: data on more than 200,000 urinary stone analyses. J Urol. 2011; 185(4): 1304-1311. doi: 10.1016/j.juro.2010.11.050.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sanchez-Martin FM, Millan Rodriguez F, Esquena Fernandez S, et al. Incidence and prevalence of published studies about urolithiasis in Spain. A review. Actas Urol Esp. 2007; 31(5): 511-520.</mixed-citation><mixed-citation xml:lang="en">Sanchez-Martin FM, Millan Rodriguez F, Esquena Fernandez S, et al. Incidence and prevalence of published studies about urolithiasis in Spain. A review. Actas Urol Esp. 2007; 31(5): 511-520.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Arias Funez F, Garcia Cuerpo E, Lovaco Castellanos F, et al. Epidemiology of urinary lithiasis in our unit. Clinical course in time and predictive factors. Arch Esp Urol. 2000; 53(4): 343-347.</mixed-citation><mixed-citation xml:lang="en">Arias Funez F, Garcia Cuerpo E, Lovaco Castellanos F, et al. Epidemiology of urinary lithiasis in our unit. Clinical course in time and predictive factors. Arch Esp Urol. 2000; 53(4): 343-347.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Maalouf NM, Cameron MA, Moe OW, et al. Low urine pH: a novel feature of the metabolic syndrome. Clin J Am Soc Nephrol. 2007; 2(5): 883-888. doi: 10.2215/CJN.00250107.</mixed-citation><mixed-citation xml:lang="en">Maalouf NM, Cameron MA, Moe OW, et al. Low urine pH: a novel feature of the metabolic syndrome. Clin J Am Soc Nephrol. 2007; 2(5): 883-888. doi: 10.2215/CJN.00250107.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Maalouf NM, Sakhaee K, Parks JH, et al. Association of urinary pH with body weight in nephrolithiasis. Kidney Int. 2004; 65(4): 1422-1425. doi: 10.1111/j.1523-1755.2004.00532.x.</mixed-citation><mixed-citation xml:lang="en">Maalouf NM, Sakhaee K, Parks JH, et al. Association of urinary pH with body weight in nephrolithiasis. Kidney Int. 2004; 65(4): 1422-1425. doi: 10.1111/j.1523-1755.2004.00532.x.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ekeruo WO, Tan YH, Young MD, et al. Metabolic risk factors and the impact of medical therapy on the management of nephrolithiasis in obese patients. J Urol. 2004; 172(1): 159-163. doi: 10.1097/01.ju.0000125195.94613.22.</mixed-citation><mixed-citation xml:lang="en">Ekeruo WO, Tan YH, Young MD, et al. Metabolic risk factors and the impact of medical therapy on the management of nephrolithiasis in obese patients. J Urol. 2004; 172(1): 159-163. doi: 10.1097/01.ju.0000125195.94613.22.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pak CYC, Sakhaee K, Moe OW, et al. Biochemical profile of stone-forming patients with diabetes mellitus. Urology. 2003; 61(3): 523-527. doi: 10.1016/s0090-4295(02)02439-8.</mixed-citation><mixed-citation xml:lang="en">Pak CYC, Sakhaee K, Moe OW, et al. Biochemical profile of stone-forming patients with diabetes mellitus. Urology. 2003; 61(3): 523-527. doi: 10.1016/s0090-4295(02)02439-8.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sakhaee K, Adams-Huet B, Moe OW, et al. Pathophysiologic basis for normouricosuric uric acid nephrolithiasis. Kidney Int. 2002; 62(3): 971-979. doi: 10.1046/j.1523-1755.2002.00530.x.</mixed-citation><mixed-citation xml:lang="en">Sakhaee K, Adams-Huet B, Moe OW, et al. Pathophysiologic basis for normouricosuric uric acid nephrolithiasis. Kidney Int. 2002; 62(3): 971-979. doi: 10.1046/j.1523-1755.2002.00530.x.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Alvarez-Nemegyei J, Medina-Escobedo M, Villanueva-Jorge S, et al. Prevalence and risk factors for urolithiasis in primary gout: is a reappraisal needed? J Rheumatol. 2005; 32(11): 2189-2191.</mixed-citation><mixed-citation xml:lang="en">Alvarez-Nemegyei J, Medina-Escobedo M, Villanueva-Jorge S, et al. Prevalence and risk factors for urolithiasis in primary gout: is a reappraisal needed? J Rheumatol. 2005; 32(11): 2189-2191.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
