<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pirogovestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Национального медико-хирургического центра им. Н.И. Пирогова</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Pirogov National Medical &amp; Surgical Center</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8255</issn><issn pub-type="epub">2782-3628</issn><publisher><publisher-name>Национальный медико-хирургический Центр им. Н.И. Пирогова</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25881/20728255_2026_21_1_54</article-id><article-id custom-type="elpub" pub-id-type="custom">pirogovestnik-534</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ЧАСТОТА И СТЕПЕНЬ ВЛИЯНИЯ РЕТРОГРАДНЫХ КРОВОТОКОВ В ГЛУБОКИХ ВЕНАХ НА ФОРМИРОВАНИЕ ПАТОЛОГИЧЕСКОЙ СЕГМЕНТАРНОЙ ГИПЕРВОЛЕМИИ ГОЛЕНИ У ПАЦИЕНТОВ С ХРОНИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ ВЕН</article-title><trans-title-group xml:lang="en"><trans-title>FREQUENCY AND DEGREE OF INFLUENCE OF RETROGRADE BLOOD FLOWS IN DEEP VEINS FOR THE FORMATION OF PATHOLOGICAL SEGMENTAL HYPERVOLEMIA OF THE CALF IN PATIENTS WITH CVD</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Санников</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Sannikov</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владимир</p></bio><bio xml:lang="en"><p>Vladimir</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Приволжский исследовательский медицинский университет», (Владимирский филиал)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Privolzsky Research Medical University (Vladimir Branch)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>21</day><month>03</month><year>2026</year></pub-date><volume>21</volume><issue>1</issue><fpage>54</fpage><lpage>63</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Санников А.Б., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Санников А.Б.</copyright-holder><copyright-holder xml:lang="en">Sannikov A.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://submit.pirogov-vestnik.ru/jour/article/view/534">https://submit.pirogov-vestnik.ru/jour/article/view/534</self-uri><abstract><p>Цель исследования – определение степени влияния ретроградных кровотоков в глубоких венах различных сегментов нижних конечностей на формирование патологической сегментарной гиперволемии голени у пациентов с хроническими заболеваниями вен (ХЗВ) различных клинических классов по классификации СЕАР.</p><sec><title>Методы</title><p>Методы. 380 здоровых лиц и 896 пациентов с ХЗВ было обследовано c использованием ультразвукового сканирования (УЗДС) и пневмоплетизмографии (ППГ). Выявление ретроградного кровотока при УЗДС осуществлялось в подвздошно-бедренном, бедренно-подколенном и подколенно-суральном венозных сегментах. Протяженность рефлюкса классифицировалась по трем степеням. Для ППГ оценки интенсивности венозного оттока рассчитывали: величину максимальной емкости вен голени, объем их опорожнения, величину максимального венозного оттока, отношение этих величин на обеих конечностях.</p></sec><sec><title>Результаты</title><p>Результаты. Было установлено, что ретроградные кровотоки в глубоких венах продолжительностью более 3 с имеют значение на прогрессирование хронической венозной недостаточности (ХВН) у пациентов с ХЗВ. Наиболее ощутимым является влияние ретроградных кровотоков на прогрессирование ХВН при их локализации на уровне подколенной и внутримышечных вен голени. При этом ППГ индекс венозной емкости (VCI) имеет статистически значимые отличия по мере прогрессирования ХЗВ, что может свидетельствовать о развивающейся у пациентов по мере прогрессирования заболевания патологической сегментарной венозной гиперволемии голени.</p></sec><sec><title>Вывод</title><p>Вывод. Наличие протяженного подколенно-сурального рефлюкса у пациентов с ХЗВ оказывает влияние на формирование патологической сегментарной гиперволемии голени и является гемодинамическим фактором развития ХВН.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Abstract</title><p>Abstract. Objectives. The aim of the study was to determine the degree of influence of retrograde blood flow in the deep veins of various segments of the lower extremities on the formation of pathological segmental hypervolemia of the lower leg in patients with chronic venous diseases (CVD) of various clinical classes according to the CEAR classification.</p></sec><sec><title>Methods</title><p>Methods. 380 healthy individuals and 896 patients with CVD were examined using ultrasound scanning (USDS) and pneumoplethysmography (PPG). Retrograde blood flow was detected in the ilio-femoral, femoral-popliteal and popliteal-suric venous segments. The extent of reflux was classified into three degrees. To assess the intensity of venous outflow, the following values were calculated: the maximum capacity of the lower leg veins, the volume of their emptying, the maximum venous outflow, and the ratio of these values on both extremities.</p></sec><sec><title>Results</title><p>Results. It was found that retrograde blood flow in deep veins lasting more than 3 seconds is important for the progression of chronic venous insufficiency (CVI) in patients with CVD. The most noticeable effect of retrograde blood flow on the progression of CVI is when they are localized at the level of the popliteal and intramuscular veins of the lower leg. At the same time, the pneumoplethysmographic venous capacity index (VCI) has statistically significant differences as CVD progresses, which may indicate that patients develop pathological segmental venous hypervolemia of the lower leg as the disease progresses.</p></sec><sec><title>Conclusion</title><p>Conclusion. The presence of prolonged popliteal-sural reflux in patients with CVD affects the formation of pathological segmental hypervolemia of the lower leg and is a hemodynamic factor in the development of CVI.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хронические заболевания вен</kwd><kwd>диагностика нарушений гемодинамики</kwd><kwd>венозная пневмоплетизмография</kwd><kwd>рефлюкс в глубоких венах</kwd><kwd>гемодинамическая значимость венозного рефлюкса</kwd><kwd>патологическая сегментарная венозная гиперволемия голени</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic venous diseases</kwd><kwd>noninvasive diagnosis of hemodynamic disorders</kwd><kwd>venous reflux in deep veins</kwd><kwd>significance of venous reflux</kwd><kwd>air plethysmography</kwd><kwd>pathological segmental venous hypervolemia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kistner RL. Primary venous valve incompetence of the leg. Am J Surg. 1980; 140(2): 218-224. doi: 10.1016/0002-9610(80)90010-0.</mixed-citation><mixed-citation xml:lang="en">Kistner RL. Primary venous valve incompetence of the leg. Am J Surg. 1980; 140(2): 218-224. doi: 10.1016/0002-9610(80)90010-0.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Савельев В.С., Думпе Э.П., Яблоков Е.Г. Болезни магистральных вен. – М.: Медицина, 1972.</mixed-citation><mixed-citation xml:lang="en">Savel’ev VS, Dumpe EP, YAblokov E.G. Bolezni magistral’nyh ven. M.: Medicina; 1972. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Веденский А.Н. Варикозная болезнь. – Л.: Медицина, 1983.</mixed-citation><mixed-citation xml:lang="en">Vedenskij AN. Varikoznaya bolezn’. L.: Medicina; 1983. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Константинова Г.Д., Зубарев А.Р., Градусов Е.Г. Флебология. – М.: Видар-M, 2000.</mixed-citation><mixed-citation xml:lang="en">Konstantinova GD, Zubarev AR, Gradusov EG. Flebologiya. M.: Vidar-M; 2000. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Perrin M. Reconstructive surgery for deep venous reflux: a report on 144 cases. Cardiovascular Surgery. 2000; 8(4): 246-255. doi:10.1016/s0967-2109(00)00019-3.</mixed-citation><mixed-citation xml:lang="en">Perrin M. Reconstructive surgery for deep venous reflux: a report on 144 cases. Cardiovascular Surgery. 2000; 8(4): 246-255. doi:10.1016/s0967-2109(00)00019-3.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Савельев В.С., Гологорский В.А., Кириенко А.И. Флебология: Руководство для врачей под редакцией В.С. Савельева. – М.: Медицина, 2001.</mixed-citation><mixed-citation xml:lang="en">Savel’ev VS, Gologorskij VA, Kirienko AI. Flebologiya: Rukovodstvo dlya vrachej pod redakciej V.S.Savel’eva. M.: Medicina; 2001. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Maleti O, Perrin M. Reconstructive surgery for deep vein reflux in the lower limbs: techniques, results and indications. Eur J Vas. Endovasc Surg. 2011; 41: 837-848. doi: 10.1016/j.ejvs.2011.02.013.</mixed-citation><mixed-citation xml:lang="en">Maleti O, Perrin M. Reconstructive surgery for deep vein reflux in the lower limbs: techniques, results and indications. Eur J Vas. Endovasc Surg. 2011; 41: 837-848. doi: 10.1016/j.ejvs.2011.02.013.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Gloviczki P, Comerota AJ, Dalsing MC. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011; 53: 2S-48S. doi: 10.1016/j.jvs.2011.01.079.</mixed-citation><mixed-citation xml:lang="en">Gloviczki P, Comerota AJ, Dalsing MC. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011; 53: 2S-48S. doi: 10.1016/j.jvs.2011.01.079.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Российские клинические рекомендации по диагностике и лечению хронических заболеваний вен // Флебология. – 2018. – Т.12. – №3.</mixed-citation><mixed-citation xml:lang="en">Russian clinical guidelines for the diagnosis and treatment of chronic venous diseases. Flebologiya. 2018; 12(3). (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Walsh JC, Bergan JJ, Beeman S, Comer TP. Femoral venous reflux abolished by greater saphenous vein stripping. Ann Vasc Surg. 1994; 8: 566-70. doi: 10.1007/bf02017413.</mixed-citation><mixed-citation xml:lang="en">Walsh JC, Bergan JJ, Beeman S, Comer TP. Femoral venous reflux abolished by greater saphenous vein stripping. Ann Vasc Surg. 1994; 8: 566-70. doi: 10.1007/bf02017413.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sales CM, Bilof ML, Petrillo KA, Luka NL. Correction of lower extremity deep venous incompetence by ablation of superficial venous reflux. Ann Vasc Surg. 1996; 10: 186-9. doi: 10.1007/bf02000764.</mixed-citation><mixed-citation xml:lang="en">Sales CM, Bilof ML, Petrillo KA, Luka NL. Correction of lower extremity deep venous incompetence by ablation of superficial venous reflux. Ann Vasc Surg. 1996; 10: 186-9. doi: 10.1007/bf02000764.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ting ACW, Cheng SWK, Ho P, Poon JTC, Wu LLH, Cheung GCY. Reduction in deep vein reflux after concomitant subfascial endoscopic perforating vein surgery and superficial vein ablation in advanced primary chronic venous insufficiency. Journal of Vascular Surgery. 2006; 43(3): 546-550. doi: 10.1016/j.jvs.2005.11.020.</mixed-citation><mixed-citation xml:lang="en">Ting ACW, Cheng SWK, Ho P, Poon JTC, Wu LLH, Cheung GCY. Reduction in deep vein reflux after concomitant subfascial endoscopic perforating vein surgery and superficial vein ablation in advanced primary chronic venous insufficiency. Journal of Vascular Surgery. 2006; 43(3): 546-550. doi: 10.1016/j.jvs.2005.11.020.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Marston WA, Brabham VW, Mendes R, Berndt D, Weiner M, Keagy B. The importance of deep venous reflux velocity as a determinant of outcome in patients with combined superficial and deep venous reflux treated with endovenous saphenous ablation. J Vasc Surg. 2008; 48(2): 400-406. doi: 10.1016/j.jvs.2008.03.039.</mixed-citation><mixed-citation xml:lang="en">Marston WA, Brabham VW, Mendes R, Berndt D, Weiner M, Keagy B. The importance of deep venous reflux velocity as a determinant of outcome in patients with combined superficial and deep venous reflux treated with endovenous saphenous ablation. J Vasc Surg. 2008; 48(2): 400-406. doi: 10.1016/j.jvs.2008.03.039.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kim SM, Jung IM, Chung JK. Improvement of deep vein reflux following radiofrequency ablation for saphenous vein incompetence. Phlebology: The Journal of Venous Disease. 2017; 32(1): 55-60. doi: 10.1177/0268355516629867.</mixed-citation><mixed-citation xml:lang="en">Kim SM, Jung IM, Chung JK. Improvement of deep vein reflux following radiofrequency ablation for saphenous vein incompetence. Phlebology: The Journal of Venous Disease. 2017; 32(1): 55-60. doi: 10.1177/0268355516629867.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Proebstle TM, Alm BJ, Gockeritz O. Five-year results from the prospective European multicentre cohort study on radiofrequency segmental thermal ablation for incometent great saphenous veins. Br J Surg. 2015; 102: 212-218. doi: 10.1002/bjs.9679.</mixed-citation><mixed-citation xml:lang="en">Proebstle TM, Alm BJ, Gockeritz O. Five-year results from the prospective European multicentre cohort study on radiofrequency segmental thermal ablation for incometent great saphenous veins. Br J Surg. 2015; 102: 212-218. doi: 10.1002/bjs.9679.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Jayaraj A. Deep Venous Reflux. Book Chapter in Venous Disorders. 2018: 29-38. doi: 10.1007/978-981-13-1108-6_3.</mixed-citation><mixed-citation xml:lang="en">Jayaraj A. Deep Venous Reflux. Book Chapter in Venous Disorders. 2018: 29-38. doi: 10.1007/978-981-13-1108-6_3.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Maleti O, Lugli M, Perrin M. After Superficial Ablation for Superficial Reflux Associated with Primary Deep Axial Reflux, Can Variable Outcomes be Caused by Deep Venous Valve Anomalies? European Journal of Vascular and Endovascular Surgery. 2017; 53(2): 229-236. doi: 10.1016/j.ejvs.2016.10.009.</mixed-citation><mixed-citation xml:lang="en">Maleti O, Lugli M, Perrin M. After Superficial Ablation for Superficial Reflux Associated with Primary Deep Axial Reflux, Can Variable Outcomes be Caused by Deep Venous Valve Anomalies? European Journal of Vascular and Endovascular Surgery. 2017; 53(2): 229-236. doi: 10.1016/j.ejvs.2016.10.009.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Adgerinos ED, Geroulakos G. Ablate early the superficial reflux but don’t neglect deep reflux or obstruction. Journal of Vascular Surgery: Venous and Lymphatic Disorders. 2019; 7(3): 315-316. doi: 10.1016/jvsv.2018.12.015.</mixed-citation><mixed-citation xml:lang="en">Adgerinos ED, Geroulakos G. Ablate early the superficial reflux but don’t neglect deep reflux or obstruction. Journal of Vascular Surgery: Venous and Lymphatic Disorders. 2019; 7(3): 315-316. doi: 10.1016/jvsv.2018.12.015.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Санников А.Б., Емельяненко В.М., Рачков М.А. Особенности строения внутримышечных вен голени в норме и при хронических заболеваниях по данным мультиспиральной компьютерной флебографии // Флебология. – 2018. – №4. – C.292-299. doi: 10/17116/flebo201812041292. (In Russ.)</mixed-citation><mixed-citation xml:lang="en">Sannikov AB, Emel’yanenko VM, Rachkov MA. Structural features of the intramuscular veins of the lower leg in normal and chronic diseases according to multispiral computed phlebography. Flebologiya. 2018; 4: 292-299. doi: 10/17116/flebo201812041292. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Danielsson G, Eklof Bo, Kistner RL. Deep axial reflux, an important contributor to skin changes or ulcer in chronic venous disease. J Vasc Surg. 2003; 38: 1336-1341. doi: 10.1016/S0741-5214(03)00907-8.</mixed-citation><mixed-citation xml:lang="en">Danielsson G, Eklof Bo, Kistner RL. Deep axial reflux, an important contributor to skin changes or ulcer in chronic venous disease. J Vasc Surg. 2003; 38: 1336-1341. doi: 10.1016/S0741-5214(03)00907-8.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bergan J, Pascerella L. Venous Anatomy, Physiology, and Pathophysiology. Book Chapter in The Vein Book. Academic Press, 2007; 39-45. doi: 10.1016/b978-012369515-4/50007-7.</mixed-citation><mixed-citation xml:lang="en">Bergan J, Pascerella L. Venous Anatomy, Physiology, and Pathophysiology. Book Chapter in The Vein Book. Academic Press, 2007; 39-45. doi: 10.1016/b978-012369515-4/50007-7.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Van-Rij A.M, Solomon C, Christie R. Anatomic and physiologic characteristics of venous ulceration. J Vasc Surg. 1994; 20(5): 759-764. doi: 10.1016/s0741-5214(94)70163-6.</mixed-citation><mixed-citation xml:lang="en">Van-Rij A.M, Solomon C, Christie R. Anatomic and physiologic characteristics of venous ulceration. J Vasc Surg. 1994; 20(5): 759-764. doi: 10.1016/s0741-5214(94)70163-6.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Шанина Е.Ю., Гузь В.С., Сидоров Р.В. Ультразвуковая диагностика клапанной дисфункции при хронической венозной недостаточности // Ангиология и сосудистая хирургия. – 1999. – Т.2 (приложение 1). – С.111-112.</mixed-citation><mixed-citation xml:lang="en">SHanina EYU, Guz’ VS, Sidorov RV. Ul’trazvukovaya diagnostika klapannoj disfunkcii pri hronicheskoj venoznoj nedostatochnosti. Angiologiya i sosudistaya hirurgiya. 1999; 2(1): 111-112. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Стойко Ю.М., Лыткин М.И., Шайдаков Е.В. Венозная гипертензия в системе полых вен. – Санкт-Петербург, 2002.</mixed-citation><mixed-citation xml:lang="en">Stojko YUM, Lytkin MI, SHajdakov EV. Venoznaya gipertenziya v sisteme polyh ven. Sankt-Peterburg; 2002. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Гавриленко А.В., Вахратьян П.Е. Ошибки в обследовании и лечении больных с варикозной болезнью нижних конечностей и их роль в возникновении рецидива болезни // Ангиология и сосудистая хирургия. – 2008. – Т.14. – №1. – С.61-64.</mixed-citation><mixed-citation xml:lang="en">Gavrilenko AV, Vahrat’yan PE. Oshibki v obsledovanii i lechenii bol’nyh s varikoznoj bolezn’yu nizhnih konechnostej i ih rol’ v vozniknovenii recidiva bolezni. Angiologiya i sosudistaya hirurgiya. 2008; 14(1): 61-64. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Rasmussen L, Lawaetz M, Bjoern L, Blemings A, Eklof B. Randomized clinical trial comparing endovenous laser ablation and stripping of the great saphenous vein with clinical and duplex outcome after 5 years. Journal of the International Union of Angiology. 2013; 58(2): 421-426. doi: 10.1016/j.jvs.2012.12.048.</mixed-citation><mixed-citation xml:lang="en">Rasmussen L, Lawaetz M, Bjoern L, Blemings A, Eklof B. Randomized clinical trial comparing endovenous laser ablation and stripping of the great saphenous vein with clinical and duplex outcome after 5 years. Journal of the International Union of Angiology. 2013; 58(2): 421-426. doi: 10.1016/j.jvs.2012.12.048.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Velden SK, Lawaetz M, De Maeseneer MGR, Hollestein L, Nijsten T, et al. Predictors of recanalization of the great saphenous vein in randomized controlled trials 1 year after endovenous thermal ablation. Eur J Vasc Endovasc Surg. 2016; 52(2): 234-241. doi: 10.1016/j.ejvs.2016.01.021.</mixed-citation><mixed-citation xml:lang="en">Van der Velden SK, Lawaetz M, De Maeseneer MGR, Hollestein L, Nijsten T, et al. Predictors of recanalization of the great saphenous vein in randomized controlled trials 1 year after endovenous thermal ablation. Eur J Vasc Endovasc Surg. 2016; 52(2): 234-241. doi: 10.1016/j.ejvs.2016.01.021.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">O´Donnell TF, Balk EM, Dermody M, Tangney E, Lafrati MD. Recurrence of varicose veins after endovenous Ablation of the great saphenous vein in randomized trials. J Vasc Surg Venous Lymphat Disord. 2016; 4(1): 97-105. doi: 10.1016/j.jvsv.2014.11.004.</mixed-citation><mixed-citation xml:lang="en">O´Donnell TF, Balk EM, Dermody M, Tangney E, Lafrati MD. Recurrence of varicose veins after endovenous Ablation of the great saphenous vein in randomized trials. J Vasc Surg Venous Lymphat Disord. 2016; 4(1): 97-105. doi: 10.1016/j.jvsv.2014.11.004.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Tsuyoshi S. Three-year results of endovascular laser ablation of great and small saphenous vein in patients with varicose veins. Jap J Phlebology. 2018; 29(3): 419-425. doi: 10.714/phlebol.18-18.</mixed-citation><mixed-citation xml:lang="en">Tsuyoshi S. Three-year results of endovascular laser ablation of great and small saphenous vein in patients with varicose veins. Jap J Phlebology. 2018; 29(3): 419-425. doi: 10.714/phlebol.18-18.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Игнатьев И.М., Бредихин Р.А., Сафиуллина Л.И., Обухова Т.Н. Диагностика и лечение послеоперационных рецидивов варикозной болезни // Ангиология и сосудистая хирургия. – 2003. – Т.9. – №2. – С.73-79.</mixed-citation><mixed-citation xml:lang="en">Ignat’ev IM, Bredihin RA, Safiullina LI, Obuhova T.N. Diagnostika i lechenie posleoperacionnyh recidivov varikoznoj bolezni. Angiologiya i sosudistaya hirurgiya. 2003; 9(2): 73-79. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Бурлева Е.П., Тюрин С.А., Смирнов О.А., Фасхиев Р.Р. Сравнительные трехлетние результаты флебэктомий и термоабляций при варикозной болезни нижних конечностей // Ангиология и сосудистая хирургия. – 2018. – Т.24. – №2. – С.82-90.</mixed-citation><mixed-citation xml:lang="en">Burleva EP, Tyurin SA, Smirnov OA, Faskhiev RR. Sravnitel’nye trekhletnie rezul’taty flebektomij i termoablyacij pri varikoznoj bolezni nizhnih konechnostej. Angiologiya i sosudistaya hirurgiya. 2018; 24(2): 82-90. (In Russ.)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
