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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pirogovestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Национального медико-хирургического центра им. Н.И. Пирогова</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Pirogov National Medical &amp; Surgical Center</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8255</issn><issn pub-type="epub">2782-3628</issn><publisher><publisher-name>Национальный медико-хирургический Центр им. Н.И. Пирогова</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25881/20728255_2025_20_4_S1_97</article-id><article-id custom-type="elpub" pub-id-type="custom">pirogovestnik-440</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>МОРФОФУНКЦИОНАЛЬНЫЕ ИЗМЕНЕНИЯ ДРЕНАЖНОЙ СИСТЕМЫ ГЛАЗА  И ОФТАЛЬМОГИПЕРТЕНЗИЯ ПРИ ЭНДОКРИННОЙ ОФТАЛЬМОПАТИИ</article-title><trans-title-group xml:lang="en"><trans-title>MORPHOFUNCTIONAL CHANGES OF THE OCULAR DRAINAGE SYSTEM AND OCULAR HYPERTENSION IN THYROID EYE DISEASE</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Махмудов</surname><given-names>Р. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Makhmudov</surname><given-names>R. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ташкент</p></bio><bio xml:lang="en"><p>Tashkent</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ташкентский государственный медицинский университет</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Tashkent State Medical University</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>11</month><year>2025</year></pub-date><volume>20</volume><issue>4</issue><issue-title>приложение 1</issue-title><fpage>97</fpage><lpage>100</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Махмудов Р.Ш., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Махмудов Р.Ш.</copyright-holder><copyright-holder xml:lang="en">Makhmudov R.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://submit.pirogov-vestnik.ru/jour/article/view/440">https://submit.pirogov-vestnik.ru/jour/article/view/440</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Клинико-функциональная оценка нарушений офтальмотонуса и их последствий у пациентов с эндокринной офтальмопатией, с определением роли структурных изменений шлеммова канала в развитии офтальмогипертензии.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Обследованы 92 пациента (150 глаз), распределённых на 4 группы: ЭО с офтальмогипертензией, ЭО без офтальмогипертензии, первичная открытоугольная глаукома и контрольная группа. Проводилось комплексное офтальмологическое обследование, включающее визометрию, офтальмотонометрию, тонографию, периметрию, ОКТ переднего сегмента и диска зрительного нерва, а также морфометрическую оценку шлеммова канала. Использовались шкалы NOSPECS и CAS.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. У пациентов с ЭО и офтальмогипертензией выявлены достоверно более тяжёлые проявления заболевания по шкале NOSPECS, снижение коэффициента оттока (0,12 ± 0,02 мм³/мин/мм рт. ст.), повышение ВГД и КБ, а также морфологическое сужение шлеммова канала. Эти параметры коррелировали с толщиной RNFL и тяжестью зрительных нарушений, сближаясь по офтальмогидродинамическому профилю с первичной глаукомой.</p></sec><sec><title>Заключение</title><p>Заключение. Нарушение офтальмотонуса при ЭО связано с морфофункциональными изменениями дренажной системы глаза и требует ранней диагностики с применением ОКТ и тонографии для своевременного выявления офтальмогипертензии и профилактики глаукоматозных осложнений.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose. To perform a clinical and functional evaluation of ocular tone disturbances and their consequences in patients with thyroid eye disease (TED), with an emphasis on determining the role of structural changes in Schlemm’s canal in the development of ocular hypertension.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods. Ninety-two patients (150 eyes) were examined and divided into four groups: TED with ocular hypertension, TED without ocular hypertension, primary open-angle glaucoma, and healthy controls. Comprehensive ophthalmological assessment included visual acuity testing, tonometry, tonography, perimetry, optical coherence tomography (OCT) of the anterior segment and optic nerve head, as well as morphometric analysis of Schlemm’s canal. The NOSPECS and CAS scales were used to assess disease activity.</p></sec><sec><title>Results and Discussion</title><p>Results and Discussion. Patients with TED and ocular hypertension demonstrated significantly more severe disease manifestations according to the NOSPECS scale, a decreased outflow coefficient (0,12±0,02 mm³/min/mm Hg), elevated intraocular pressure and ocular rigidity coefficient, and morphological narrowing of Schlemm’s canal. These parameters correlated with retinal nerve fiber layer (RNFL) thickness and the severity of visual field defects, closely resembling the ocular hydrodynamic profile of primary open-angle glaucoma.</p></sec><sec><title>Conclusion</title><p>Conclusion. Ocular tone disturbances in thyroid eye disease are associated with morphofunctional changes of the ocular drainage system and require early diagnosis using OCT and tonography for timely detection of ocular hypertension and prevention of glaucomatous complications.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>эндокринная офтальмопатия</kwd><kwd>офтальмогипертензия</kwd><kwd>внутриглазное давление</kwd><kwd>шлеммов канал</kwd><kwd>оптическая когерентная томография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thyroid eye disease</kwd><kwd>ocular hypertension</kwd><kwd>intraocular pressure</kwd><kwd>Schlemm’s canal</kwd><kwd>optical coherence tomography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Betzler BK, Young SM, Sundar G. Intraocular Pressure and Glaucoma in Thyroid Eye Disease. 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