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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pirogovestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Национального медико-хирургического центра им. Н.И. Пирогова</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Pirogov National Medical &amp; Surgical Center</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8255</issn><issn pub-type="epub">2782-3628</issn><publisher><publisher-name>Национальный медико-хирургический Центр им. Н.И. Пирогова</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25881/20728255_2025_20_1_161</article-id><article-id custom-type="elpub" pub-id-type="custom">pirogovestnik-285</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>АУТОТРАНСПЛАНТАЦИЯ СОСКОВО-АРЕОЛЯРНОГО КОМПЛЕКСА У БОЛЬНЫХ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ</article-title><trans-title-group xml:lang="en"><trans-title>AUTOTRANSPLANTATION OF THE NIPLE-AREOLAR COMPLEX IN PATIENTS WITH BREAST CANCER</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаповалов</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Shapovalov</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">shapovalov_serg@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кчеусо</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kcheuso</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хрусталева</surname><given-names>И. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Khrustaleva</surname><given-names>I. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазаренко</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazarenko</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Всероссийский центр экстренной и радиационной медицины им. А.М. Никифорова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Nikiforov’s All-Russian Center for Emergency and Radiation Medicine of the Emergencies Ministry of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First St. Petersburg State Medical University named after I.I. acad. I.P. Pavlov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>09</day><month>03</month><year>2025</year></pub-date><volume>20</volume><issue>1</issue><fpage>161</fpage><lpage>163</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шаповалов С.Г., Кчеусо А.В., Хрусталева И.Э., Лазаренко Е.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шаповалов С.Г., Кчеусо А.В., Хрусталева И.Э., Лазаренко Е.С.</copyright-holder><copyright-holder xml:lang="en">Shapovalov S.G., Kcheuso A.V., Khrustaleva I.E., Lazarenko E.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://submit.pirogov-vestnik.ru/jour/article/view/285">https://submit.pirogov-vestnik.ru/jour/article/view/285</self-uri><abstract><p>Обоснование: Рак молочной железы (РМЖ) занимает первое место в структуре онкологических заболеваний женщин. Их доля среди трудоспособного возраста составляет 60%. Пятнадцать лет назад основным хирургическим способом лечения РМЖ являлась мастэктомия. Данная операция приводила к инвалидизации женщины, влияя на снижение ее социальной адаптации, наносился колоссальный психологический урон.Цель: обосновать на основе клинических наблюдений показания к реконструкции сосково-ареолярного комплекса (САК) методом свободной аутопересадки у пациентов с раком молочных желёз, оценить безопасность данной методики. Сравнить эстетические результаты аутотрансплантации САК с отсроченной реконструкцией САК.Материалы и методы: Приведены клинические наблюдения 3 пациенток, которым проведено хирургическое лечение по поводу РМЖ в 2021–2022 гг. Всем выполнена одномоментная реконструкция молочной железы с реплантацией САК. Предоперационные измерения включали расстояние от яремной вырезки грудины до соска (в см), расстояние от соска до подгрудной борозды (в см), ширину основания молочной железы (в см) и диаметр САК (в мм). Степень птоза классифицировали в соответствии с системами Regnault и Brink.Результаты: Три клинических наблюдения.Заключение: Методика аутотрансплантации САК у больных раком молочной железы в обязательном порядке требует интраоперационного срочного гистологического исследования подсосковой зоны и последующего его планового гистологического исследования. Одномоментная аутотрансплантация САК является безопасным и надежным методом для больных, которым противопоказана мастэктомия с сохранением САК и показана в случаях, когда после срочного гистологического исследования подсосковой зоны исключено наличие опухолевых клеток.</p></abstract><trans-abstract xml:lang="en"><p>Grounding: Breast cancer (BC) ranks first in the structure of oncological diseases in women. Their share among the working age is 60%. Fifteen years ago, the main surgical method of treating BC was mastectomy. This operation led to the disability of a woman, affecting the decrease in her social adaptation, and caused colossal psychological damage.Purpose: to substantiate, on the basis of clinical observations, the indications for the reconstruction of the nipple-areolar complex (NAC) by the method of free autotransplantation in patients with breast cancer, to evaluate the safety of this technique. To compare the aesthetic results of autotransplantation of the NAC with delayed reconstruction of the NAC.Materials and methods: Clinical examples of 3 patients who underwent surgical treatment for BC in 2021–2022 are given. All underwent simultaneous reconstruction of the mammary gland with replantation of the NAC. Preoperative measurements included the distance from the sternal notch to the nipple (in cm), the distance from the nipple to the inframammary sulcus (in cm), the width of the base of the mammary gland (in cm), and the diameter of the NAC (in mm). The degree of ptosis was classified according to the classification systems of Regnault and Brink.Results: Three clinical cases.Conclusion: The technique of NAC autotransplantation in patients with breast cancer necessarily requires an intraoperative urgent histological examination of the submammary area and its subsequent planned histological examination. One-stage NAC autotransplantation is a safe and reliable method for patients for whom mastectomy with NAC preservation is contraindicated and is indicated in cases where the presence of tumor cells is excluded after an urgent histological examination of the submammary area.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сосково-ареолярный комплекс</kwd><kwd>реконструкция</kwd><kwd>аутотрансплантация</kwd><kwd>рак молочной железы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>nipple-areolar complex</kwd><kwd>reconstruction</kwd><kwd>autotransplantation</kwd><kwd>breast cancer</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">De Angelis R, et al. Breast cancer survivors in the United States: Geographic variability and times trends, 2005-2015. Cancer. 2009; 115: 1954-1966. doi: 10.1016%2FS1043-321X(09)79395-6.</mixed-citation><mixed-citation xml:lang="en">De Angelis R, et al. Breast cancer survivors in the United States: Geographic variability and times trends, 2005-2015. Cancer. 2009; 115: 1954-1966. doi: 10.1016%2FS1043-321X(09)79395-6.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Злокачественные новообразования в России в 2009 году (заболеваемость и смертность). Под ред. В.И. Чиссова, В.В. Старинского, Г.В. Петровой. М.: МНИОИ им. П.А. Герцена, 2011. – 260 с.</mixed-citation><mixed-citation xml:lang="en">Malignant neoplasms in Russia in 2009 (morbidity and mortality). V.I. Chissov, V.V. Starinsky, G.V. Petrova, editors. M.: MNIOI named after P.A. Herzen, 2011. 260 p. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Злокачественные новообразования в России в 2018 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М.: МНИОИ им. П.А. Герцена, 2019. – 250 с.</mixed-citation><mixed-citation xml:lang="en">Malignant neoplasms in Russia in 2018 (morbidity and mortality). A.D. Kaprin, V.V. Starinsky, G.V. Petrova, editors. M.: MNIOI named after P.A. Herzen, 2019. 250 p. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Pusic AL, Matros E, Fine N, et al. Patient-Reported Outcomes 1 Year After Immediate Breast Reconstruction: Results of the Mastectomy Reconstruction Outcomes Consortium Study. J Clinical Oncology. 2017; 35(22): 2499-2503. doi: 10.1200%2FJCO.2016.69.9561.</mixed-citation><mixed-citation xml:lang="en">Pusic AL, Matros E, Fine N, et al. Patient-Reported Outcomes 1 Year After Immediate Breast Reconstruction: Results of the Mastectomy Reconstruction Outcomes Consortium Study. J Clinical Oncology. 2017; 35(22): 2499-2503. doi: 10.1200%2FJCO.2016.69.9561.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gerber B, Krause A, Dieterich M, Kundt G, Reimer T. The oncological safety of skin sparing mastectomy with conservation of the nippleareola complex and autologous reconstruction: An extended follow-up study. Ann Surg. 2009; 249: 461-468. doi: 10.1097%2F01.SLA.0000077922.38307.cd.</mixed-citation><mixed-citation xml:lang="en">Gerber B, Krause A, Dieterich M, Kundt G, Reimer T. The oncological safety of skin sparing mastectomy with conservation of the nippleareola complex and autologous reconstruction: An extended follow-up study. Ann Surg. 2009; 249: 461-468. doi: 10.1097%2F01.SLA.0000077922.38307.cd.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Jabor MA. Nipple-areola reconstruction: satisfaction and clinical determinants. Plast. Reconstr. Surg. 2002; 110: 457-463; discussion 464-465 Pusic AL, Matros E, Fine N, Bushe E, Gordillo GM, Hamill JB, Kim HM, Qi J, Albornoz C, Klassen AF, Wilkins EG. Patient-Reported Outcomes 1 Year After Immediate Breast Reconstruction: Results of the Mastectomy Reconstruction Outcomes Consortium Study. J Clinical Oncology. 2017; 35(22): 2499-2503. doi: 10.1200%2FJCO.2016.69.9561.</mixed-citation><mixed-citation xml:lang="en">Jabor MA. Nipple-areola reconstruction: satisfaction and clinical determinants. Plast. Reconstr. Surg. 2002; 110: 457-463; discussion 464-465 Pusic AL, Matros E, Fine N, Bushe E, Gordillo GM, Hamill JB, Kim HM, Qi J, Albornoz C, Klassen AF, Wilkins EG. Patient-Reported Outcomes 1 Year After Immediate Breast Reconstruction: Results of the Mastectomy Reconstruction Outcomes Consortium Study. J Clinical Oncology. 2017; 35(22): 2499-2503. doi: 10.1200%2FJCO.2016.69.9561.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Millard DR Jr, Devine J Jr, Warren WD. Breast reconstruction: A plea for saving the uninvolved nipple. Am J Surg. 1971; 122: 763-764. doi: 10.1016/0002-9610(71)90441-7.</mixed-citation><mixed-citation xml:lang="en">Millard DR Jr, Devine J Jr, Warren WD. Breast reconstruction: A plea for saving the uninvolved nipple. Am J Surg. 1971; 122: 763-764. doi: 10.1016/0002-9610(71)90441-7.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">A Review of 101 Consecutive Subcutaneous Mastectomies and Male Chest Contouring Using the Concentric Circular and Free Nipple Graft Techniques in Female-to-Male Transgender Patients. Plastic and Reconstructive Surgery. 2017; 139(6): 1262e.</mixed-citation><mixed-citation xml:lang="en">A Review of 101 Consecutive Subcutaneous Mastectomies and Male Chest Contouring Using the Concentric Circular and Free Nipple Graft Techniques in Female-to-Male Transgender Patients. Plastic and Reconstructive Surgery. 2017; 139(6): 1262e.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Brink RR. Management of true ptosis of the breast. Plast Reconstr Surg. 1993; 91: 657-662. doi: 10.1097/PRS.0000000000003388.</mixed-citation><mixed-citation xml:lang="en">Brink RR. Management of true ptosis of the breast. Plast Reconstr Surg. 1993; 91: 657-662. doi: 10.1097/PRS.0000000000003388.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Regnault P. Breast ptosis: Definition and treatment. Clin Plast Surg. 1976; 3: 193-203. doi: 10.1200%2FJCO.2016.69.9561.</mixed-citation><mixed-citation xml:lang="en">Regnault P. Breast ptosis: Definition and treatment. Clin Plast Surg. 1976; 3: 193-203. doi: 10.1200%2FJCO.2016.69.9561.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
