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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pirogovestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Национального медико-хирургического центра им. Н.И. Пирогова</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Pirogov National Medical &amp; Surgical Center</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8255</issn><issn pub-type="epub">2782-3628</issn><publisher><publisher-name>Национальный медико-хирургический Центр им. Н.И. Пирогова</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25881/20728255_2024_19_4_107</article-id><article-id custom-type="elpub" pub-id-type="custom">pirogovestnik-235</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>ПАЛЛИАТИВНЫЕ МЕТОДЫ ЛЕЧЕНИЯ ПАЦИЕНТОВ С НЕОПЕРАБЕЛЬНЫМИ ОПУХОЛЯМИ ПЕРИАМПУЛЯРНОЙ ГЕПАТОБИЛИАРНОЙ ЗОНЫ: СРАВНЕНИЕ ЭФФЕКТИВНОСТИ МЕТОДОВ ДЕКОМПРЕССИИ ЖЕЛЧЕВЫВОДЯЩИХ ПУТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>PALLIATIVE METHODS OF TREATMENT OF PATIENTS WITH INOPERABLE PERIAMPULLARY TUMORS: COMPARISON OF THE EFFECTIVENESS OF BILIARY TRACT DECOMPRESSION METHODS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенцов</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sementsov</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">konstantinsementsov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глушков</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Glushkov</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург </p></bio><bio xml:lang="en"><p> Saint-Petersburg </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бояринов</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Boyarinov</surname><given-names>D. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург </p></bio><bio xml:lang="en"><p> Saint-Petersburg </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Буранов</surname><given-names>В. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Buranov</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург </p></bio><bio xml:lang="en"><p> Saint-Petersburg </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мянзелин</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Myanzelin</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург </p></bio><bio xml:lang="en"><p> Saint-Petersburg </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фоменко</surname><given-names>Е. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomenko</surname><given-names>E. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург </p></bio><bio xml:lang="en"><p> Saint-Petersburg </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лаушкин</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Laushkin</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург </p></bio><bio xml:lang="en"><p> Saint-Petersburg </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>СПб ГБУЗ «Госпиталь для ветеранов войн»; &#13;
ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The Saint Petersburg «Hospital for war veterans»;&#13;
NWSMU named after I. I. Mechnikov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>СПб ГБУЗ «Госпиталь для ветеранов войн»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The Saint Petersburg «Hospital for war veterans»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>19</day><month>12</month><year>2024</year></pub-date><volume>19</volume><issue>4</issue><fpage>107</fpage><lpage>113</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Семенцов К.В., Глушков Н.И., Бояринов Д.Ю., Буранов В.Э., Мянзелин М.Н., Фоменко Е.Е., Лаушкин М.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Семенцов К.В., Глушков Н.И., Бояринов Д.Ю., Буранов В.Э., Мянзелин М.Н., Фоменко Е.Е., Лаушкин М.А.</copyright-holder><copyright-holder xml:lang="en">Sementsov K.V., Glushkov N.I., Boyarinov D.Y., Buranov V.E., Myanzelin M.N., Fomenko E.E., Laushkin M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://submit.pirogov-vestnik.ru/jour/article/view/235">https://submit.pirogov-vestnik.ru/jour/article/view/235</self-uri><abstract><p>В последние годы, за счёт накопления отдалённых результатов по различным видам хирургических вмешательств в панкреатодуоденальной области, в медицинском сообществе все чаще поднимается вопрос о правильной тактике ведения пациентов с первично нерезектабельными опухолями периампулярной зоны. Такие больные нуждаются в паллиативном лечении, заключающемся в декомпрессии желчевыводящих путей, которая может улучшить состояние пациента за счет уменьшения механической желтухи и зуда, а также увеличить вероятность выживаемости, снизив уровень общего билирубина. Так, вместе с повсеместным внедрением в практику миниинвазивных методов вмешательств эндоскопический билиарный стент, устанавливающийся во время ЭРХПГ, в настоящее время признан золотым стандартом лечения таких пациентов. Однако в связи с развитием современных схем полихимиотерапии, накоплением отдаленных результатов в отношении осложнений и выживаемости пациентов после различных методов декомпрессии желчевыводящих путей, утверждение о наибольшей эффективности эндоскопических методов вызывает сомнения. Действительно, из-за увеличения продолжительности жизни пациентов количество осложнений также возросло. В результате развиваются рецидивирующаяжелтуха и холангит, требующие повторных госпитализаций в стационар с последующим проведением реконструктивных вмешательств.Проанализировав имеющиеся данные, опубликованные за последние годы в различных странах, можно сделать вывод, что в ряде случаев шунтирующие операции ничем не уступают миниинвазивным вмешательствам, а иногда, напротив, имеют ряд преимуществ. В настоящем обзоре нами проведен обширный сбор данных сравнения эффективности эндоскопических и шунтирующих операций для лечения неоперабельных больных с диагнозом «рак периампулярной зоны».</p></abstract><trans-abstract xml:lang="en"><p>In recent years, due to the accumulation of long-term results of various types of surgical interventions in the pancreaticoduodenal region, the question of the correct tactics of management of patients with primary unresectable periampullary tumors has been raised more often in the medical community. Such patients need palliative treatment consisting in biliary tract decompression, which can improve the patient’s condition by reducing mechanical jaundice and pruritus, as well as increase the probability of survival by reducing the level of total bilirubin. Thus, together with the widespread introduction of minimally invasive interventions, endoscopic biliary stent placement during ERCPG is now recognized as the gold standard for the treatment of these patients. However, due to the development of modern polychemotherapy schemes, accumulation of distant results regarding complications and survival of patients after different methods of biliary tract decompression, the statement about the greatest efficacy of endoscopic methods is questionable. Indeed, due to the increase of patients’ life expectancy the number of complications has also increased. As a result recurrent jaundice and cholangitis requiring repeated hospitalizations with subsequent reconstructive interventions develop.Having analyzed the available data published in recent years in different countries, we can conclude that in some cases bypass operations are not inferior to minimally invasive interventions, and sometimes, on the contrary, have a number of advantages. In this review, we have extensively collected data comparing the efficacy of endoscopic and bypass surgeries for the treatment of inoperable patients diagnosed with periampullary cancer.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>опухоли периампулярной зоны</kwd><kwd>рак головки поджелудочной железы</kwd><kwd>рак терминального отдела холедоха</kwd><kwd>рак большого дуоденального сосочка</kwd><kwd>шунтирующие операции</kwd><kwd>методы декомпрессии желчевыводящих путей</kwd></kwd-group><kwd-group xml:lang="en"><kwd>periampullary tumors</kwd><kwd>cancer of the pancreas</kwd><kwd>cancer of the terminal choledochus</kwd><kwd>cancer of the great duodenal papilla</kwd><kwd>shunt operations</kwd><kwd>methods of biliary decompression</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кудашкин Н.Е. 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