pirogovestnikВестник Национального медико-хирургического центра им. Н.И. ПироговаBulletin of Pirogov National Medical & Surgical Center2072-82552782-3628Национальный медико-хирургический Центр им. Н.И. Пирогова10.25881/20728255_2024_19_4_86pirogovestnik-232Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWSВЛИЯНИЕ КОРОНАРНОГО ШУНТИРОВАНИЯ НА АМИНОТИОЛЫ КРОВИ У БОЛЬНЫХ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦАTHE EFFECT OF CORONARY BYPASS SURGERY ON BLOOD AMINOTHIOLS IN PATIENTS WITH CORONARY HEART DISEASEДонцовВ. В.DontsovV. V.

Москва 

 Moscow 

vvdontsov@yandex.ruЗыбинД. И.ZybinD. I.

Москва 

 Moscow 

ИвановА. В.IvanovA. V.

Москва 

 Moscow 

ПоповМ. А.PopovM. A.

Москва 

 Moscow 

АгафоновЕ. Г.AgafonovE. G.

Москва 

 Moscow 

ШумаковД. В.ShumakovD. V.

Москва 

 Moscow 

ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»РоссияMoscow Regional Research and Clinical Institute n.a. M.F. VladimirskiyRussian FederationФГБНУ Научно-исследовательский институт общей патологии и патофизиологииРоссияInstitute of General Pathology and PathophysiologyRussian Federation2024181220241948692Copyright © Донцов В.В., Зыбин Д.И., Иванов А.В., Попов М.А., Агафонов Е.Г., Шумаков Д.В., 20242024Донцов В.В., Зыбин Д.И., Иванов А.В., Попов М.А., Агафонов Е.Г., Шумаков Д.В.Dontsov V.V., Zybin D.I., Ivanov A.V., Popov M.A., Agafonov E.G., Shumakov D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://submit.pirogov-vestnik.ru/jour/article/view/232

Ишемическая болезнь сердца (ИБС) связана с окислительным стрессом (ОС), при котором баланс нарушается, и выработка активных форм кислорода (АФК) перевешивает их элиминацию. Окислительная реакция приводит к нарушению функции клеток и может увеличить вероятность развития осложнений во время или после операции коронарного шунтирования (КШ). При патофизиологических состояниях, связанных с ОС, наблюдается общее увеличение потребности глутатиона в антиоксидантных реакциях, реакциях конъюгации и восстановлении дисульфидов белков. Данные о влиянии КШ на аминотиолы плазмы неполны и противоречивы.Плазменный пул аминотиолов, с одной стороны, оказывает существенное влияние на метаболизм глутатиона в тканях сосудов и сердца, а с другой – может отражать его нарушения. КШ, в свою очередь, можно рассматривать как процедуру, запускающую стрессовые и адаптивные механизмы, способные оказывать существенное влияние на метаболизм аминотиолов. Однако на сегодняшний день данные об этом влиянии КШ фрагментарны. Для понимания процессов, происходящих в аминотиоловой системе при ИБС и КШ, важно обнаружить не только сдвиги концентраций этих маркеров, но и выявить наличие или отсутствие их ассоциации друг с другом.

Coronary heart disease (CHD) is associated with oxidative stress (OS), in which this balance is disrupted, and the production of ROS outweighs their elimination. The oxidative reaction leads to impaired cell function and may increase the likelihood of complications during or after coronary artery bypass surgery (CABG). In pathophysiological conditions associated with OS, there is a general increase in the need for glutathione in antioxidant reactions, conjugation reactions and reduction of protein disulfides. Data on the effect of CABG on plasma aminothiols are incomplete and contradictory.The plasma pool of aminothiols, on the one hand, has a significant effect on the metabolism of glutathione in the tissues of blood vessels and the heart, and on the other hand, may reflect its disorders. CABG, in turn, can be considered as a procedure that triggers stress and adaptive mechanisms that can have a significant effect on the metabolism of aminothiols. However, to date, data on this effect of CABG are fragmentary. To understand the processes occurring in the aminothiol system in coronary heart disease and CABG, it is important to detect not only shifts in the concentrations of these markers, but also.

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The authors declare that there are no conflicts of interest present.