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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pirogovestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Национального медико-хирургического центра им. Н.И. Пирогова</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Pirogov National Medical &amp; Surgical Center</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8255</issn><issn pub-type="epub">2782-3628</issn><publisher><publisher-name>Национальный медико-хирургический Центр им. Н.И. Пирогова</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25881/20728255_2024_19_3_127</article-id><article-id custom-type="elpub" pub-id-type="custom">pirogovestnik-164</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>ВАРИКОЗНЫЕ ВЕНЫ В ПОЖИЛОМ И СТАРЧЕСКОМ ВОЗРАСТЕ: ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ</article-title><trans-title-group xml:lang="en"><trans-title>VARICOSE VEINS IN THE ELDERLY PATIENTS: PROBLEMS AND PROSPECTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ширинбек</surname><given-names>О.</given-names></name><name name-style="western" xml:lang="en"><surname>Shirinbek</surname><given-names>O.</given-names></name></name-alternatives><email xlink:type="simple">olims@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мнацаканян</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mnatsakanyan</surname><given-names>G. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Одинокова</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Odinokova</surname><given-names>S. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Многопрофильный медицинский холдинг «СМ-Клиника»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>SM-Clinic</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>25</day><month>10</month><year>2024</year></pub-date><volume>19</volume><issue>3</issue><fpage>127</fpage><lpage>135</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ширинбек О., Мнацаканян Г.В., Одинокова С.Н., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Ширинбек О., Мнацаканян Г.В., Одинокова С.Н.</copyright-holder><copyright-holder xml:lang="en">Shirinbek O., Mnatsakanyan G.V., Odinokova S.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://submit.pirogov-vestnik.ru/jour/article/view/164">https://submit.pirogov-vestnik.ru/jour/article/view/164</self-uri><abstract><p>Варикозная болезнь нижних конечностей (ВБНК) достаточно распространена у пациентов пожилого и старческого возраста. Степень тяжести данного состояния определяется индивидуальной переносимостью симптомов варикозной болезни с учетом естественного старения организма и присутствующего коморбидного фона. Проведен обзор проблемы ВБНК в целом и сквозь призму пациентов старшей возрастной группы. Также рассмотрены преимущества и ограничения различных подходов к диагностике и лечению варикозных вен в геронтологической популяции. Среди современных методов рассмотрены эндовенозные технологии, в частности, клеевая облитерация, открывающая новые горизонты безболезненного и радикального лечения ВБНК у пациентов пожилого и старческого возраста.</p></abstract><trans-abstract xml:lang="en"><p>Varicose veins of the lower extremities are quite common in the elderly population. The severity of venous disease is determined by the individual tolerance of the symptoms of varicose veins, taking into account the natural aging of the body and the existing comorbid status. This article provides an overview of the problem of varicose veins and chronic venous insufficiency in general and through the prism of patients of the older age group. The advantages and limitations of various approaches to the diagnostics and treatment of varicose veins in the gerontological patients are discussed and presented. Endovenous treatment modalities, specifically glue ablation, open new horizons of pain-free and radical treatment of varicose veins in the elderly patients</p></trans-abstract><kwd-group xml:lang="ru"><kwd>варикозная болезнь нижних конечностей</kwd><kwd>варикозные вены</kwd><kwd>пожилой и старческий возраст</kwd><kwd>геронтологический</kwd><kwd>ЭВЛК</kwd><kwd>РЧО</kwd><kwd>клеевая облитерация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>varicose veins</kwd><kwd>superficial venous disease</kwd><kwd>elderly patients</kwd><kwd>frail patients</kwd><kwd>endovenous ablation</kwd><kwd>laser</kwd><kwd>radiofrequency and glue ablation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Azar J, Rao A, Oropallo A. Chronic venous insufficiency: a comprehensive review of management. Journal of Wound Care. 2022; 31(6): 510-519. doi: 10.12968/jowc.2022.31.6.510.</mixed-citation><mixed-citation xml:lang="en">Azar J, Rao A, Oropallo A. Chronic venous insufficiency: a comprehensive review of management. Journal of Wound Care. 2022; 31(6): 510-519. doi: 10.12968/jowc.2022.31.6.510.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ortega MÁ, Fraile-Martínez Ó, García-Montero C, et al. Understanding Chronic venous Disease: A Critical Overview of its pathophysiology and medical management. Journal of Clinical Medicine. 2021; 10(15): 3239. doi: 10.3390/jcm10153239.</mixed-citation><mixed-citation xml:lang="en">Ortega MÁ, Fraile-Martínez Ó, García-Montero C, et al. Understanding Chronic venous Disease: A Critical Overview of its pathophysiology and medical management. Journal of Clinical Medicine. 2021; 10(15): 3239. doi: 10.3390/jcm10153239.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Azhdari M, Zilaee M, Karandish M, et al. Red vine leaf extract (AS 195) can improve some signs and symptoms of chronic venous insufficiency, a systematic review. PTR Phytotherapy Research (Print). 2020; 34(10): 2577-2585. doi: 10.1002/ptr.6705.</mixed-citation><mixed-citation xml:lang="en">Azhdari M, Zilaee M, Karandish M, et al. Red vine leaf extract (AS 195) can improve some signs and symptoms of chronic venous insufficiency, a systematic review. PTR Phytotherapy Research (Print). 2020; 34(10): 2577-2585. doi: 10.1002/ptr.6705.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Mayrovitz HN, Aoki KC, Colón JLL. Chronic venous insufficiency with emphasis on the geriatric population. Curēus. June 2023. doi: 10.7759/cureus.40687.</mixed-citation><mixed-citation xml:lang="en">Mayrovitz HN, Aoki KC, Colón JLL. Chronic venous insufficiency with emphasis on the geriatric population. Curēus. June 2023. doi: 10.7759/cureus.40687.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Shehab AW, Eleshra A, Fouda E, Elwakeel H, Farag MK. Randomized prospective comparative study of platelet-rich plasma versus conventional compression in treatment of post-phlebitic venous ulcer. Vascular. 2022; 31(6): 1222-1229. doi: 10.1177/17085381221104629.</mixed-citation><mixed-citation xml:lang="en">Shehab AW, Eleshra A, Fouda E, Elwakeel H, Farag MK. Randomized prospective comparative study of platelet-rich plasma versus conventional compression in treatment of post-phlebitic venous ulcer. Vascular. 2022; 31(6): 1222-1229. doi: 10.1177/17085381221104629.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Helmy Y, Farouk N, Ali Y, et al. Objective assessment of Platelet-Rich Plasma (PRP) potentiality in the treatment of Chronic leg Ulcer: RCT on 80 patients with Venous ulcer. Journal of Cosmetic Dermatology (Print). 2021; 20(10): 3257-3263. doi: 10.1111/jocd.14138.</mixed-citation><mixed-citation xml:lang="en">Helmy Y, Farouk N, Ali Y, et al. Objective assessment of Platelet-Rich Plasma (PRP) potentiality in the treatment of Chronic leg Ulcer: RCT on 80 patients with Venous ulcer. Journal of Cosmetic Dermatology (Print). 2021; 20(10): 3257-3263. doi: 10.1111/jocd.14138.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Weller C, Bouguettaya A, Team V, Flegg JA, Kasza J, Jayathilake C. Associations between patient, treatment, or wound-level factors and venous leg ulcer healing: Wound characteristics are the key factors in determining healing outcomes. Wound Repair and Regeneration. 2019; 28(2): 211-218. doi: 10.1111/wrr.12773.</mixed-citation><mixed-citation xml:lang="en">Weller C, Bouguettaya A, Team V, Flegg JA, Kasza J, Jayathilake C. Associations between patient, treatment, or wound-level factors and venous leg ulcer healing: Wound characteristics are the key factors in determining healing outcomes. Wound Repair and Regeneration. 2019; 28(2): 211-218. doi: 10.1111/wrr.12773.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Longobardi P, Hartwig V, Santarella L, et al. Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. A randomized controlled clinical trial comparing conventional with hyperbaric oxygen treatment. Wound Repair and Regeneration. 2020; 28(6): 856-866. doi: 10.1111/wrr.12853.</mixed-citation><mixed-citation xml:lang="en">Longobardi P, Hartwig V, Santarella L, et al. Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. A randomized controlled clinical trial comparing conventional with hyperbaric oxygen treatment. Wound Repair and Regeneration. 2020; 28(6): 856-866. doi: 10.1111/wrr.12853.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chinchalongporn W, Tanmit P, Pruekprasert K, et al. Prevalence and predictors of combined &gt;50% iliocaval venous obstruction and superficial venous reflux in chronic venous insufficiency patients with healed or active venous leg ulcer. Journal of Vascular Surgery Venous and Lymphatic Disorders (Print). 2023; 11(3): 502-509. doi: 10.1016/j.jvsv.2022.11.006.</mixed-citation><mixed-citation xml:lang="en">Chinchalongporn W, Tanmit P, Pruekprasert K, et al. Prevalence and predictors of combined &gt;50% iliocaval venous obstruction and superficial venous reflux in chronic venous insufficiency patients with healed or active venous leg ulcer. Journal of Vascular Surgery Venous and Lymphatic Disorders (Print). 2023; 11(3): 502-509. doi: 10.1016/j.jvsv.2022.11.006.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Vuylsteke M, Colman R, Thomis S, Guillaume G, Van Quickenborne D, Staelens I. An epidemiological survey of venous disease among general practitioner attendees in different geographical regions on the globe: The final results of the Vein Consult Program. Angiology. 2018; 69(9): 779-785. doi: 10.1177/0003319718759834.</mixed-citation><mixed-citation xml:lang="en">Vuylsteke M, Colman R, Thomis S, Guillaume G, Van Quickenborne D, Staelens I. An epidemiological survey of venous disease among general practitioner attendees in different geographical regions on the globe: The final results of the Vein Consult Program. Angiology. 2018; 69(9): 779-785. doi: 10.1177/0003319718759834.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kim Y, Png CYM, Sumpio BJ, DeCarlo C, Dua A. Defining the human and health care costs of chronic venous insufficiency. Seminars in Vascular Surgery. 2021; 34(1): 59-64. doi: 10.1053/j.semvascsurg.2021.02.007.</mixed-citation><mixed-citation xml:lang="en">Kim Y, Png CYM, Sumpio BJ, DeCarlo C, Dua A. Defining the human and health care costs of chronic venous insufficiency. Seminars in Vascular Surgery. 2021; 34(1): 59-64. doi: 10.1053/j.semvascsurg.2021.02.007.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Galsinh H, Singh K, Smith L. Lipodermatosclerosis: the common skin condition often treated as cellulitis. Journal of the Royal College of Physicians of Edinburgh. 2019; 49(1): 41-42. doi: 10.4997/jrcpe.2019.110.</mixed-citation><mixed-citation xml:lang="en">Galsinh H, Singh K, Smith L. Lipodermatosclerosis: the common skin condition often treated as cellulitis. Journal of the Royal College of Physicians of Edinburgh. 2019; 49(1): 41-42. doi: 10.4997/jrcpe.2019.110.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mayrovitz HN, Wong S, Mancuso C. Venous, arterial, and neuropathic leg ulcers with emphasis on the geriatric population. Curēus. 2023. doi: 10.7759/cureus.38123.</mixed-citation><mixed-citation xml:lang="en">Mayrovitz HN, Wong S, Mancuso C. Venous, arterial, and neuropathic leg ulcers with emphasis on the geriatric population. Curēus. 2023. doi: 10.7759/cureus.38123.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Łastowiecka-Moras E. Standing and sitting postures at work and symptoms of venous insufficiency – results from questionnaires and a Doppler ultrasound study. International Journal of Occupational Safety and Ergonomics. 2020; 27(4): 963-969. doi: 10.1080/10803548.2020.1834232.</mixed-citation><mixed-citation xml:lang="en">Łastowiecka-Moras E. Standing and sitting postures at work and symptoms of venous insufficiency – results from questionnaires and a Doppler ultrasound study. International Journal of Occupational Safety and Ergonomics. 2020; 27(4): 963-969. doi: 10.1080/10803548.2020.1834232.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Mahapatra S, Ramakrishna P, Gupta B, Anusha AM, Para MA. Correlation of obesity &amp; comorbid conditions with chronic venous insufficiency: Results of a single-centre study. Indian Journal of Medical Research (New Delhi). 2018; 147(5): 471. doi: 10.4103/ijmr.ijmr_1844_16.</mixed-citation><mixed-citation xml:lang="en">Mahapatra S, Ramakrishna P, Gupta B, Anusha AM, Para MA. Correlation of obesity &amp; comorbid conditions with chronic venous insufficiency: Results of a single-centre study. Indian Journal of Medical Research (New Delhi). 2018; 147(5): 471. doi: 10.4103/ijmr.ijmr_1844_16.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Yun MJ, Kim YK, Kang D, et al. A study on prevalence and risk factors for varicose veins in nurses at a university hospital. Safety and Health at Work (Seoul). 2018; 9(1): 79-83. doi: 10.1016/j.shaw.2017.08.005.</mixed-citation><mixed-citation xml:lang="en">Yun MJ, Kim YK, Kang D, et al. A study on prevalence and risk factors for varicose veins in nurses at a university hospital. Safety and Health at Work (Seoul). 2018; 9(1): 79-83. doi: 10.1016/j.shaw.2017.08.005.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Lurie F, Passman MA, Meisner MJ, et al. The 2020 update of the CEAP classification system and reporting standards. Journal of Vascular Surgery Venous and Lymphatic Disorders. 2020; 8(3): 342-352. doi: 10.1016/j.jvsv.2019.12.075.</mixed-citation><mixed-citation xml:lang="en">Lurie F, Passman MA, Meisner MJ, et al. The 2020 update of the CEAP classification system and reporting standards. Journal of Vascular Surgery Venous and Lymphatic Disorders. 2020; 8(3): 342-352. doi: 10.1016/j.jvsv.2019.12.075.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Orhurhu V, Chu R, Xie K, et al. Management of Lower Extremity Pain from Chronic Venous Insufficiency: A Comprehensive Review. Cardiology and Therapy (Internet). 2021; 10(1): 111-140. doi: 10.1007/s40119-021-00213-x.</mixed-citation><mixed-citation xml:lang="en">Orhurhu V, Chu R, Xie K, et al. Management of Lower Extremity Pain from Chronic Venous Insufficiency: A Comprehensive Review. Cardiology and Therapy (Internet). 2021; 10(1): 111-140. doi: 10.1007/s40119-021-00213-x.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Shams E, Mayrovitz HN. Contrast-Induced Nephropathy: A review of mechanisms and risks. Curēus. 2021. doi: 10.7759/cureus.14842.</mixed-citation><mixed-citation xml:lang="en">Shams E, Mayrovitz HN. Contrast-Induced Nephropathy: A review of mechanisms and risks. Curēus. 2021. doi: 10.7759/cureus.14842.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Blake A, Cruzval-O’Reilly E, Sayed C. Cellulitis mimics in the geriatric patient. Current Geriatrics Reports. 2020; 9(4): 192-198. doi: 10.1007/s13670-020-00334-6.</mixed-citation><mixed-citation xml:lang="en">Blake A, Cruzval-O’Reilly E, Sayed C. Cellulitis mimics in the geriatric patient. Current Geriatrics Reports. 2020; 9(4): 192-198. doi: 10.1007/s13670-020-00334-6.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Michener A, Heath B, Crnich C, et al. Infections in Older Adults: A Case-Based Discussion Series emphasizing antibiotic stewardship. MedEdPORTAL. September 2018. doi:10.15766/mep_2374-8265.10754.</mixed-citation><mixed-citation xml:lang="en">Michener A, Heath B, Crnich C, et al. Infections in Older Adults: A Case-Based Discussion Series emphasizing antibiotic stewardship. MedEdPORTAL. September 2018. doi:10.15766/mep_2374-8265.10754.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Sudduth CL, Greene AK. Primary lymphedema: update on genetic basis and management. Advances in Wound Care (New Rochelle, NY Print). 2022; 11(7): 374-381. doi: 10.1089/wound.2020.1338.</mixed-citation><mixed-citation xml:lang="en">Sudduth CL, Greene AK. Primary lymphedema: update on genetic basis and management. Advances in Wound Care (New Rochelle, NY Print). 2022; 11(7): 374-381. doi: 10.1089/wound.2020.1338.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Wong ML, Eaton PK, Zanichelli C, Moore C, Hegarty CE, MacDonald N. The prevalence of undiagnosed postoperative lower limb lymphedema among gynecological oncology patients. European Journal of Surgical Oncology. 2022; 48(5): 1167-1172. doi: 10.1016/j.ejso.2021.12.464.</mixed-citation><mixed-citation xml:lang="en">Wong ML, Eaton PK, Zanichelli C, Moore C, Hegarty CE, MacDonald N. The prevalence of undiagnosed postoperative lower limb lymphedema among gynecological oncology patients. European Journal of Surgical Oncology. 2022; 48(5): 1167-1172. doi: 10.1016/j.ejso.2021.12.464.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshihara M, Shimono R, Tsuru S, et al. Risk factors for late-onset lower limb lymphedema after gynecological cancer treatment: A multi-institutional retrospective study. European Journal of Surgical Oncology. 2020; 46(7): 1334-1338. doi: 10.1016/j.ejso.2020.01.033.</mixed-citation><mixed-citation xml:lang="en">Yoshihara M, Shimono R, Tsuru S, et al. Risk factors for late-onset lower limb lymphedema after gynecological cancer treatment: A multi-institutional retrospective study. European Journal of Surgical Oncology. 2020; 46(7): 1334-1338. doi: 10.1016/j.ejso.2020.01.033.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Rockson SG. Bioimpedance analysis of lower extremity lymphedema. Lymphatic Research and Biology. 2020; 18(2): 98. doi: 10.1089/lrb.2020. 29085.sr.</mixed-citation><mixed-citation xml:lang="en">Rockson SG. Bioimpedance analysis of lower extremity lymphedema. Lymphatic Research and Biology. 2020; 18(2): 98. doi: 10.1089/lrb.2020. 29085.sr.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Mayrovitz HN, Arzanova E, Somarriba S, Eisa S. Factors affecting interpretation of tissue dielectric constant (TDC) in assessing breast cancer treatment related lymphedema (BCRL). Lymphology. 2019; 52(2): 92-102.</mixed-citation><mixed-citation xml:lang="en">Mayrovitz HN, Arzanova E, Somarriba S, Eisa S. Factors affecting interpretation of tissue dielectric constant (TDC) in assessing breast cancer treatment related lymphedema (BCRL). Lymphology. 2019; 52(2): 92-102.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Mayrovitz HN. Assessing lower extremity lymphedema using upper and lower extremity tissue dielectric constant ratios: method and normal reference values. Lymphatic Research and Biology. 2019; 17(4): 457-464. doi: 10.1089/lrb.2018.0039.</mixed-citation><mixed-citation xml:lang="en">Mayrovitz HN. Assessing lower extremity lymphedema using upper and lower extremity tissue dielectric constant ratios: method and normal reference values. Lymphatic Research and Biology. 2019; 17(4): 457-464. doi: 10.1089/lrb.2018.0039.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Mayrovitz HN, Mikulka A, Woody D. Minimum Detectable Changes Associated with Tissue Dielectric Constant Measurements as Applicable to Assessing Lymphedema Status. Lymphatic Research and Biology. 2019; 17(3): 322-328. doi: 10.1089/lrb.2018.0052.</mixed-citation><mixed-citation xml:lang="en">Mayrovitz HN, Mikulka A, Woody D. Minimum Detectable Changes Associated with Tissue Dielectric Constant Measurements as Applicable to Assessing Lymphedema Status. Lymphatic Research and Biology. 2019; 17(3): 322-328. doi: 10.1089/lrb.2018.0052.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Mayrovitz HN, Arzanova E, Somarriba S, Eisa S. Reference values for assessing localized hand lymphedema using interhand tissue dielectric constant ratios. Lymphatic Research and Biology. 2018; 16(5): 442-445. doi: 10.1089/lrb.2017.0065.</mixed-citation><mixed-citation xml:lang="en">Mayrovitz HN, Arzanova E, Somarriba S, Eisa S. Reference values for assessing localized hand lymphedema using interhand tissue dielectric constant ratios. Lymphatic Research and Biology. 2018; 16(5): 442-445. doi: 10.1089/lrb.2017.0065.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma SK, Mudgal SK, Mandal A. Thyroid disease in older people: Nursing perspectives. Thyroid Research and Practice. 2020; 17(3): 110-117, doi: 10.4103/trp.trp_25_20.</mixed-citation><mixed-citation xml:lang="en">Sharma SK, Mudgal SK, Mandal A. Thyroid disease in older people: Nursing perspectives. Thyroid Research and Practice. 2020; 17(3): 110-117, doi: 10.4103/trp.trp_25_20.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma SK, Mudgal SK, Mandal A. Thyroid disease in older people: nursing perspectives . Thyroid Res Prac. 2020; 17: 110-117.</mixed-citation><mixed-citation xml:lang="en">Sharma SK, Mudgal SK, Mandal A. Thyroid disease in older people: nursing perspectives . Thyroid Res Prac. 2020; 17: 110-117.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kılınç F, Akbaş A, Şener S, Hayran Y, Aktaş A. Cutaneous findings in patients with chronic venous insufficiency. Journal of Cosmetic Dermatology (Print). 2021; 21(5): 2106-2112. doi: 10.1111/jocd.14337.</mixed-citation><mixed-citation xml:lang="en">Kılınç F, Akbaş A, Şener S, Hayran Y, Aktaş A. Cutaneous findings in patients with chronic venous insufficiency. Journal of Cosmetic Dermatology (Print). 2021; 21(5): 2106-2112. doi: 10.1111/jocd.14337.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mackie H, Thompson B, Suami H, et al. Differentiation of lipoedema from bilateral lower limb lymphoedema by imaging assessment of indocyanine green lymphography. Clinical Obesity (Print). 2023; 13(3). doi: 10.1111/cob.12588.</mixed-citation><mixed-citation xml:lang="en">Mackie H, Thompson B, Suami H, et al. Differentiation of lipoedema from bilateral lower limb lymphoedema by imaging assessment of indocyanine green lymphography. Clinical Obesity (Print). 2023; 13(3). doi: 10.1111/cob.12588.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Rasmussen JC, Aldrich MB, Fife CE, Herbst KL, Sevick-Muraca EM. Lymphatic function and anatomy in early stages of lipedema. Obesity (Silver Spring, Md). 2022; 30(7): 1391-1400. doi: 10.1002/oby.23458.</mixed-citation><mixed-citation xml:lang="en">Rasmussen JC, Aldrich MB, Fife CE, Herbst KL, Sevick-Muraca EM. Lymphatic function and anatomy in early stages of lipedema. Obesity (Silver Spring, Md). 2022; 30(7): 1391-1400. doi: 10.1002/oby.23458.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Wollina U. Lipedema – An update. Dermatologic Therapy. 2018; 32(2): e12805. doi: 10.1111/dth.12805.</mixed-citation><mixed-citation xml:lang="en">Wollina U. Lipedema – An update. Dermatologic Therapy. 2018; 32(2): e12805. doi: 10.1111/dth.12805.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Silva WT, Ávila MR, De Oliveira LFF, et al. Differences in health-related quality of life in patients with mild and severe chronic venous insufficiency: A systematic review and meta-analysis. Journal of Vascular Nursing. 2021; 39(4): 126-133. doi: 10.1016/j.jvn.2021.09.002.</mixed-citation><mixed-citation xml:lang="en">Silva WT, Ávila MR, De Oliveira LFF, et al. Differences in health-related quality of life in patients with mild and severe chronic venous insufficiency: A systematic review and meta-analysis. Journal of Vascular Nursing. 2021; 39(4): 126-133. doi: 10.1016/j.jvn.2021.09.002.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Poulose D, Deo K, Gogineni JM, et al. Correlation of venous clinical severity score with dermatology life quality Index among patients with chronic venous insufficiency: a Cross-Sectional study. Curēus. 2021. doi: 10.7759/cureus.17654.</mixed-citation><mixed-citation xml:lang="en">Poulose D, Deo K, Gogineni JM, et al. Correlation of venous clinical severity score with dermatology life quality Index among patients with chronic venous insufficiency: a Cross-Sectional study. Curēus. 2021. doi: 10.7759/cureus.17654.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Baylis RA, Smith NL, Klarin D, Fukaya E. Epidemiology and Genetics of venous thromboembolism and Chronic venous Disease. Circulation Research. 2021; 128(12): 1988-2002. doi: 10.1161/circresaha.121.318322.</mixed-citation><mixed-citation xml:lang="en">Baylis RA, Smith NL, Klarin D, Fukaya E. Epidemiology and Genetics of venous thromboembolism and Chronic venous Disease. Circulation Research. 2021; 128(12): 1988-2002. doi: 10.1161/circresaha.121.318322.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Cires-Drouet R, Fangyang L, Rosenberger S, et al. High prevalence of chronic venous disease among health care workers in the United States. Journal of Vascular Surgery Venous and Lymphatic Disorders. 2020; 8(2): 224-230. doi: 10.1016/j.jvsv.2019.10.017.</mixed-citation><mixed-citation xml:lang="en">Cires-Drouet R, Fangyang L, Rosenberger S, et al. High prevalence of chronic venous disease among health care workers in the United States. Journal of Vascular Surgery Venous and Lymphatic Disorders. 2020; 8(2): 224-230. doi: 10.1016/j.jvsv.2019.10.017.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Ansorge C, Miocic J, Schauer F. Skin diseases in hospitalized geriatrics: a 9-year analysis from a University Dermatology Center in Germany. Archives of Dermatological Research. 2021; 314(5): 427-437. doi: 10.1007/s00403-021-02244-9.</mixed-citation><mixed-citation xml:lang="en">Ansorge C, Miocic J, Schauer F. Skin diseases in hospitalized geriatrics: a 9-year analysis from a University Dermatology Center in Germany. Archives of Dermatological Research. 2021; 314(5): 427-437. doi: 10.1007/s00403-021-02244-9.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Belmin J, Donadio C, Jarzebowski W, Genranmayeh K, Valembois L, Lafuente-Lafuente C. The value of B-type natriuretic peptide plasma concentrations in very old people with chronic peripheral oedema. Archives of Cardiovascular Diseases. 2020; 113(5): 332-340. doi: 10.1016/j.acvd.2019.12.009.</mixed-citation><mixed-citation xml:lang="en">Belmin J, Donadio C, Jarzebowski W, Genranmayeh K, Valembois L, Lafuente-Lafuente C. The value of B-type natriuretic peptide plasma concentrations in very old people with chronic peripheral oedema. Archives of Cardiovascular Diseases. 2020; 113(5): 332-340. doi: 10.1016/j.acvd.2019.12.009.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Raffetto JD. Pathophysiology of chronic venous disease and venous ulcers. ˜the oeSurgical Clinics of North America/Surgical Clinics of North America. 2018; 98(2): 337-347. doi: 10.1016/j.suc.2017.11.002.</mixed-citation><mixed-citation xml:lang="en">Raffetto JD. Pathophysiology of chronic venous disease and venous ulcers. ˜the oeSurgical Clinics of North America/Surgical Clinics of North America. 2018; 98(2): 337-347. doi: 10.1016/j.suc.2017.11.002.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Klonizakis M. The role of microcirculatory dysfunction in the pathophysiology and treatment of venous leg ulcers. JAMA Dermatology. 2019; 155(7): 861. doi: 10.1001/jamadermatol.2019.0591.</mixed-citation><mixed-citation xml:lang="en">Klonizakis M. The role of microcirculatory dysfunction in the pathophysiology and treatment of venous leg ulcers. JAMA Dermatology. 2019; 155(7): 861. doi: 10.1001/jamadermatol.2019.0591.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang J, Yuan Z, Mo CK, et al. The global burden of cardiovascular diseases and type 2 diabetes attributable to low physical activity, 1990–2019: an analysis from the global burden of disease study. Frontiers in Cardiovascular Medicine. 2023; 10. doi: 10.3389/fcvm.2023.1247705.</mixed-citation><mixed-citation xml:lang="en">Zhang J, Yuan Z, Mo CK, et al. The global burden of cardiovascular diseases and type 2 diabetes attributable to low physical activity, 1990–2019: an analysis from the global burden of disease study. Frontiers in Cardiovascular Medicine. 2023; 10. doi: 10.3389/fcvm.2023.1247705.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Patton D, Avşar P, Sayeh A, et al. A meta-review of the impact of compression therapy on venous leg ulcer healing. International Wound Journal. 2022; 20(2): 430-447. doi: 10.1111/iwj.13891.</mixed-citation><mixed-citation xml:lang="en">Patton D, Avşar P, Sayeh A, et al. A meta-review of the impact of compression therapy on venous leg ulcer healing. International Wound Journal. 2022; 20(2): 430-447. doi: 10.1111/iwj.13891.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Akrivou D, Perlepe G, Kirgou P, Gourgoulianis K, Malli F. Pathophysiological Aspects of aging in Venous Thromboembolism: an update. Medicina. 2022; 58(8): 1078. doi: 10.3390/medicina58081078.</mixed-citation><mixed-citation xml:lang="en">Akrivou D, Perlepe G, Kirgou P, Gourgoulianis K, Malli F. Pathophysiological Aspects of aging in Venous Thromboembolism: an update. Medicina. 2022; 58(8): 1078. doi: 10.3390/medicina58081078.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Ширинбек О. Справочник хирурга-флеболога. – Москва: ГЭОТАР-Медиа, 2024. – 144 с.</mixed-citation><mixed-citation xml:lang="en">Shirinbek O. Handbook of a phlebologist surgeon. Moscow: GEOTAR-Media, 2024. 144 p. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Ширинбек О., Мнацаканян Г.В., Одинокова С.Н. Цианоакрилатная клеевая облитерация варикозных вен в реальной клинической практике: двухлетние результаты лечения. Амбулаторная хирургия. – 2022. – №19(1). – С.132-139. doi: 10.21518/1995-1477-2022-19-1-132-139.</mixed-citation><mixed-citation xml:lang="en">Shirinbek O, Mnatsakanyan GV, Odinokova SN. Cyanoacrylate adhesive Closure in the Real-World Practice: 2-Year results of varicose vein Treatment. Ambulatornaâ Hirurgiâ. 2022; 19(1): 132-139. (In Russ.) doi: 10.21518/1995-1477-2022-19-1-132-139.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Ширинбек О., Одинокова С.Н. Цианоакрилатная клеевая облитерация подкожных вен // Флебология. – 2021. – №15(4). – С.297-303. doi: 10.17116/flebo202115041297.</mixed-citation><mixed-citation xml:lang="en">Shirinbek O, Odinokova SN. Cyanoacrylate Adhesive Closure of Saphenous Veins. Journal of Venous Disorders. 2021; 15(4): 297-303. (In Russ.) doi: 10.17116/flebo202115041297.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Ширинбек О., Одинокова С.Н. Клеевая облитерация в лечении варикозной болезни у пациентов пожилого и старческого возраста // Ангиология и сосудистая хирургия. – 2021. – Т.27. – №2. – С.879-881.</mixed-citation><mixed-citation xml:lang="en">Shirinbek O, Odinokova SN. Glue ablation of varicose veins in the elderly patients. Angiyologiya i Sosudistaya khirurgia. 2021; 27(2):879-881. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
