<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pirogovestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Национального медико-хирургического центра им. Н.И. Пирогова</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Pirogov National Medical &amp; Surgical Center</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8255</issn><issn pub-type="epub">2782-3628</issn><publisher><publisher-name>Национальный медико-хирургический Центр им. Н.И. Пирогова</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25881/20728255_2024_19_3_70</article-id><article-id custom-type="elpub" pub-id-type="custom">pirogovestnik-151</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ОНКОЛОГИЧЕСКАЯ ТРАНСФОРМАЦИЯ ДИВЕРТИКУЛЯРНОЙ БОЛЕЗНИ ТОЛСТОЙ КИШКИ. СОЧЕТАНИЕ ИЛИ ЗАКОНОМЕРНЫЙ ПОСЛЕДОВАТЕЛЬНЫЙ ПРОЦЕСС?</article-title><trans-title-group xml:lang="en"><trans-title>ONCOLOGICAL TRANSFORMATION OF DIVERTICULAR COLON DISEASE. A COMBINATION OR A REGULAR SEQUENTIAL PROCESS?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левчук</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Levchuk</surname><given-names>A. L.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдуллаев</surname><given-names>А. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdullaev</surname><given-names>A. E.</given-names></name></name-alternatives><email xlink:type="simple">abakar070@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медико-хирургический Центр&#13;
им. Н.И. Пирогова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov National Medical and Surgical Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГКБ СМП</institution><country>Россия</country></aff><aff xml:lang="en"><institution>GKB SMP</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>24</day><month>10</month><year>2024</year></pub-date><volume>19</volume><issue>3</issue><fpage>70</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Левчук А.Л., Абдуллаев А.Э., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Левчук А.Л., Абдуллаев А.Э.</copyright-holder><copyright-holder xml:lang="en">Levchuk A.L., Abdullaev A.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://submit.pirogov-vestnik.ru/jour/article/view/151">https://submit.pirogov-vestnik.ru/jour/article/view/151</self-uri><abstract><p>Цель. Улучшить диагностику и результаты лечения больных дивертикулярной болезнью толстой кишки (ДБТК), осложненной развитием колоректального рака (КР).Материалы и методы. Проведено исследование с участием 72 больных, лечившихся в ГКБ СМП г.Владимира с 2013–2023 гг. по поводу ДБТК, осложненной острой толстокишечной непроходимостью. Мужчин было 56 (77,7%), женщин – 16 (22,2%). Средний возраст пациентов составил 56,2±11,3 лет. У всех больных в анамнезе имелись клинические проявления ДБТК. У 98% пациентов, с давностью заболевания более трех лет, было не менее трех обострений острого дивертикулита ободочной кишки в течение года. В обязательную диагностическую программу входили: общеклинические исследования, УЗИ и КТ брюшной полости и малого таза, ирригоскопия по Кнотту, фиброколоноскопия (ФКС) с гистологической верификацией. Всем пациентам при поступлении проводился комплекс лечебных мероприятий, направленных на разрешение кишечной непроходимости. У 54 (75%) больных непроходимость имела обтурационный характер. У 18 (25%) – отмечалась частичная толстокишечная непроходимость, которая разрешилась после консервативного лечения.Результаты: Основными жалобами были боли в левой половине живота, периодические подъемы температуры тела, похудание, нарушение стула по типу запоров или поносов, примесь крови в кале. В 45 (62,5%) случаях на фоне УЗ-признаков острого дивертикулита определялось опухолевидное образование в стенке кишки с признаками толстокишечной непроходимости. В 54 (75%) наблюдениях была выполнена ирригоскопия. У 26 (36,1%) опухоль локализовалась в сигмовидной кишке, 9 (12,5%) – в селезеночном изгибе ободочной кишки, 9 (12,5%) – в нисходящей кишке, 10 (13,8%) – в ректо-сигмоидном отделе толстой кишки. ФКС с биопсией выполнена в 18 (25%) случаях. На фоне ДБТК у 10 (13,8%) больных выявлена опухоль сигмовидной кишки, в 3 (4,1%) наблюдениях опухоль ректо-сигмоидного отдела, у 2 (2,7%) пациентов рак нисходящей кишки и в 3 (4,1%) случаях – опухоль селезеночного изгиба ободочной кишки. Оперировано 72 (100%) пациента. Основными видами хирургического лечения были: обструктивная резекция сигмовидной кишки – 25 (34,7%) случаев, резекция сигмовидной кишки с наложением первичного анастомоза у 20 (27,7%) больных, резекция сигмовидной кишки с наложением превентивной петлевой трансверзостомы в 6 (8,3%) наблюдениях, у 15 (20,8%) левосторонняя гемиколэктомия с наложением первичного анастомоза, левосторонняя гемиколэктомия с наложением превентивной илеостомы по Торнболлу выполнена 6 (8,3%) пациентам. Осложнения возникли в 6 (8,3%) наблюдениях. Летальных исходов не было.Заключение: единственным радикальным методом лечения этой категории больных является только оперативное вмешательство. Применение современных методов инструментальной диагностики позволяет выбрать наиболее оптимальный объем оперативного вмешательства. При выявлении комбинированного поражения ободочной кишки – ДБТК и рак – следует выполнять вмешательство с соблюдением онкологических принципов и расширением границ резекции толстой кишки с удалением зоны распространения дивертикулеза.</p></abstract><trans-abstract xml:lang="en"><p>Objective. o improve the diagnostic capabilities and treatment results of patients with diverticular colon disease (DBTK) complicated by the development of colorectal cancer. Materials and methods. A study was conducted with the participation of 72 patients treated at the State Clinical Hospital of the NSR of Vladimir from 2013–2023 with DBTC complicated by the presence of acute colonic obstruction. There were 56 men (77.7%) and 16 women (22.2%). The average age of the patients was 56.2±11.3 years. All patients had a history of clinical manifestations of DBTC. In 98% of the cases of the studied patients, with a disease duration of more than three years, there were at least three exacerbations of acute diverticulitis of the colon during the year. The mandatory diagnostic program included: general clinical examinations, ultrasound and CT of the abdominal cavity and pelvis, Cnott irrigoscopy, fibrocolonoscopy (FCS) with histological verification. All patients, upon admission, underwent a complex of therapeutic measures aimed at resolving intestinal obstruction. In 54 (75%) patients, the obstruction was of an obstructive nature. 18 (25%) had partial colonic obstruction, which resolved after conservative treatment.Results: The main complaints of the subjects were pain in the left half of the abdomen, periodic rises in body temperature, weight loss, stool disorders such as constipation or diarrhea, blood admixture in feces. In 45 (62.5%) cases, against the background of ultrasound signs of acute diverticulitis, a tumor-like formation in the intestinal wall with signs of colonic obstruction was determined. Irrigoscopy was performed in 54 (75%) cases. In 26 (36.1%), the tumor was localized in the sigmoid colon, 9 (12.5%) – in the splenic bend of the colon, 9 (12.5%) – in the descending intestine, 10 (13.8%) – in the recto-sigmoid colon. Fibrocolonoscopy with biopsy was performed in 18 (25%) cases. Against the background of DBTC, a tumor of the sigmoid colon was detected in 10 (13.8%) patients, a tumor of the recto-sigmoid department in 3 (4.1%) cases, cancer of the descending intestine in 2 (2.7%) patients and a tumor of the splenic bend of the colon in 3 (4.1%) cases. 72 (100%) patients were operated on. The main types of surgical treatment were: obstructive resection of the sigmoid colon in 25 (34.7%) cases, resection of the sigmoid colon with the imposition of primary anastomosis in 20 (27.7%) patients, resection of the sigmoid colon with the imposition of preventive loop transversostomy in 6 (8.3%) cases, in 15 (20.8%) left-sided hemicolectomy with the imposition of primary anastomosis, left-sided hemicolectomy with Thornball preventive ileostomy was performed in 6 (8.3%) patients. Complications occurred in 6 (8.3%) cases. There were no fatalities.Conclusion: the only radical method of treatment for this category of patients is only surgical intervention. The use of modern methods of instrumental diagnostics allows you to choose the most optimal amount of surgical intervention. When detecting a combined lesion of the colon of DBTC and cancer, an intervention should be performed in compliance with oncological principles and the expansion of the boundaries of colon resection with the removal of the zone of spread of diverticulosis</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дивертикулярная болезнь толстой кишки</kwd><kwd>колоректальный рак</kwd><kwd>диагностика</kwd><kwd>хирургическое лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diverticular colon disease</kwd><kwd>colorectal cancer</kwd><kwd>diagnosis</kwd><kwd>surgical treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Осадчук М.А., Свистунов A.A., Золотовицкая А.М., Решетников В.А., Козлов В.В., Миронова Е.Д., Осадчук М.М., Огибенина Е.С. Дивертикулярная болезнь толстой кишки и ее ассоциация с полипами и колоректальным раком: клинико-инструментальное и иммуноморфологическое исследование // Медицинский вестник Северного Кавказа. – 2020. – №15(1). – С.52-57. doi: 10.14300/mnnc.2020.1501.</mixed-citation><mixed-citation xml:lang="en">Osadchuk MA, Svistunov AA, Zolotovitskaya AM, Reshetnikov VA, Kozlov VV, Mironova ED, Osadchuk MM, Ogibenina ES. Diverticular colon disease and its association with polyps and colorectal cancer: a clinical, instrumental and immunomorphological study. Medical Bulletin of the North Caucasus. 2020; 15: 52-57. (In Russ.) doi: 10.14300/mnnc.2020.1501.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Мушарапов Д.Р., Нартайлаков М.А., Хасанов С.Р., Пантелеев В.С., Фаезов Р.Р., Амирова Д.Х. Диагностика и хирургическое лечение осложненных форм дивертикулярной болезни ободочной кишки // Медицинский вестник Башкортостана. – 2019. – №5. – С.5-11.</mixed-citation><mixed-citation xml:lang="en">Musharapov DR, Nartailakov MA, Khasanov SR, Panteleev VS, Fayazov RR, Amirova DH. Diagnosis and surgical treatment of complicated forms of diverticular colon disease. Medical Bulletin of Bashkortostan. 2019; 5: 5-11. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Куляпин А.В. Диагностика дивертикулеза толстой кишки // Бюллетень ВСНЦ СО РАМН (Приложение). – 2007. – №4(56). – С.111.</mixed-citation><mixed-citation xml:lang="en">-Kulyapin AV. Diagnostics of colon diverticulosis. Bulletin of the All-Russian Scientific Research Center of the Russian Academy of Medical Sciences. 2007; 4(56): 111. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Тимербулатов М.В. и др. Опыт диагностики и лечения перфоративного дивертикулита с развитием местного ограниченного перитонита // Медицинский вестник Башкортостана. – 2018. – Т.13. – №3(75). – С.16-22.</mixed-citation><mixed-citation xml:lang="en">Timerbulatov MV, et al. The experience of diagnosis and treatment of perforated diverticulitis with the development of local limited peritonitis. Medical Bulletin of Bashkortostan. 2018; 13(3): 16-22. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Резникций П.А. Диагностика и лечение пациентов с воспалительными осложнениями дивертикулярной болезни ободочной кишки: Дис.… канд. мед. наук. Москва; 2018.</mixed-citation><mixed-citation xml:lang="en">Rezniktsii PA. Diagnosis and treatment of patients with inflammatory complications of diverticular colon disease. -dissertation Moscow; 2018 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Тимербулатов М.В. Ретроспективный анализ лечения пациентов с воспалительными осложнениями дивертикулярной болезни толстой кишки // Медицинский вестник Башкортостана. – 2017. – Т.12. – №4 (70). ‒ С.5-9.</mixed-citation><mixed-citation xml:lang="en">Timerbulatov MV. A retrospective analysis of the treatment of patients with inflammatory complications of diverticular colon disease. Medical Bulletin of Bashkortostan. 2017; 12(4): 5-9. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Дмитриев О.В., Синенченко Г.И., Вашетко Р.В. и др. Осложненные формы дивертикулярной болезни толстой кишки в практике хирурга отделения экстренной медицинской помощи // Скорая медицинская помощь. – 2019. – №4. – С.71-75.</mixed-citation><mixed-citation xml:lang="en">Dmitriev OV, Sinenchenko GI, Vashetko RV, et al. Complicated forms of diverticular colon disease in the practice of an emergency department surgeon. Emergency medical care. 2019; 4: 71-75. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Кабанов М.Ю., Глушков Н.И., Левчук А.Л. Хирургическая гастроэнтерология у больных пожилого и старческого возраста. – М., 2021. – 448 с.</mixed-citation><mixed-citation xml:lang="en">-Kabanov MYu, Glushkov NI, Levchuk AL. Surgical gastroenterology in elderly and senile patients. М., 2021: 340-356. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Meurs-Szojda MM, Terhaar sive Droste JS, Kuik DJ, et al. Diverticulosis and diverticulitis form no risk for polyps and colorectal neoplasia in 4,241 colonoscopies. Int. J. Colorectal. Dis. 2008; 23(10): 979-984.</mixed-citation><mixed-citation xml:lang="en">Meurs-Szojda MM, Terhaar sive Droste JS, Kuik DJ, et al. Diverticulosis and diverticulitis form no risk for polyps and colorectal neoplasia in 4,241 colonoscopies. Int. J. Colorectal. Dis. 2008; 23(10): 979-984.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Regula J. Diverticular Disease and Colorectal Cancer: Incidental Diagnosis or Real Association? Final Answer. J. Clin. Gastroenterol. 2016; 50(1): 39-40. doi: 10.1097/MCG.0000000000000643.</mixed-citation><mixed-citation xml:lang="en">Regula J. Diverticular Disease and Colorectal Cancer: Incidental Diagnosis or Real Association? Final Answer. J. Clin. Gastroenterol. 2016; 50(1): 39-40. doi: 10.1097/MCG.0000000000000643.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Зубрицкий В.Ф., Левчук А.Л., Шашолин М.А. Хирургическое лечение больных осложненными формами рака толстой кишки. – М.: ВиваСтар, 2019. – 350 с.</mixed-citation><mixed-citation xml:lang="en">Zubritskiy VF, Levchuk AL, Shabalin MA. Surgical treatment of patients with complicated forms of colon cancer. Moscow, 2019. 350 р. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Бондарь Г.В., Золотухин С.Э., Бондаренко А.И. Рак толстой кишки на фоне дивертикулеза: оптимизация методов лечения // Новообразование. – 2011. – №2. – С.111-123.</mixed-citation><mixed-citation xml:lang="en">Bondar GV, Zolotukhin SE, Bondarenko AI. Colon cancer on the background of diverticulosis: optimization of treatment methods. Neoplasm. 2011; 2: 111-123. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Хаджи Исмаил И.А., Воробей А.В., Семенова Ю.А. Тактика хирургического лечения пациентов с осложненной формой дивертикулярной болезни в сочетании с раком ободочной кишки // Вес. Нац. aкад. навук Беларусі. Сер. мед. навук.– 2022.– Т.19. – №2.– С.160-167. doi: 10.29235/1814-6023-2022-19-2-160-167.</mixed-citation><mixed-citation xml:lang="en">Haji Ismail IA, Vorobey AV, Semenova YuA. Tactics of surgical treatment of patients with a complicated form of diverticular disease in combination with colon cancer. Academy of Sciences of Belarus. Ser. med. sciences. 2022; 19(2): 160-167. (In Russ.) doi: 10.29235/1814-6023-2022-19-2-160-167.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Terzíc J, et al. Inflammation and colon cancer. Gastroenterology. 2010; 138(6): 2101-2114. doi: 10.1053/j.gastro.2010.01.058.</mixed-citation><mixed-citation xml:lang="en">Terzíc J, et al. Inflammation and colon cancer. Gastroenterology. 2010; 138(6): 2101-2114. doi: 10.1053/j.gastro.2010.01.058.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьев А.В., Протасова А.Э. Общие вопросы скрининга // Практ. онкология. – 2010. – Т.11. – №2. – С.53-59.</mixed-citation><mixed-citation xml:lang="en">Vorobyov AV, Protasova AE. General screening issues. Practic oncology. 2010; 11(2): 53-59. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Öistämö E, et al. Cancer and diverticulitis of the sigmoid colon. Differentiation with computed tomography versus magnetic resonance imaging: preliminary experiences // Acta Radiol. 2013; 54(3): 237-241. doi: 10.1258/ ar.2012.120543.</mixed-citation><mixed-citation xml:lang="en">Öistämö E, et al. Cancer and diverticulitis of the sigmoid colon. Differentiation with computed tomography versus magnetic resonance imaging: preliminary experiences // Acta Radiol. 2013; 54(3): 237-241. doi: 10.1258/ ar.2012.120543.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Huxley RR, et al. The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence. Int. J. Cancer. 2009; 125(1): 171-180. doi: 10.1002/ijc.24343.</mixed-citation><mixed-citation xml:lang="en">Huxley RR, et al. The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence. Int. J. Cancer. 2009; 125(1): 171-180. doi: 10.1002/ijc.24343.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hjartåker A. Subsite-specific dietary risk factors for colorectal cancer: a review of cohort studies. J. Oncol. 2013; 703854. doi: 10.1155/2013/703854.</mixed-citation><mixed-citation xml:lang="en">Hjartåker A. Subsite-specific dietary risk factors for colorectal cancer: a review of cohort studies. J. Oncol. 2013; 703854. doi: 10.1155/2013/703854.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Strate LL, et al. Obesity increases the risks of diverticulitis and diverticular bleeding. Gastroenterology. 2009; 136(1): 115-122. doi: 10.1053/j.gastro.2008.09.025.</mixed-citation><mixed-citation xml:lang="en">Strate LL, et al. Obesity increases the risks of diverticulitis and diverticular bleeding. Gastroenterology. 2009; 136(1): 115-122. doi: 10.1053/j.gastro.2008.09.025.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Hwang SS, et al. Diverticulitis in transplant patients and patients on chronic corticosteroid therapy: a systematic review. Dis. Colon Rectum. 2010; 53(12): 1699-1707. doi: 10.1007/DCR.0b013e3181f5643c.</mixed-citation><mixed-citation xml:lang="en">Hwang SS, et al. Diverticulitis in transplant patients and patients on chronic corticosteroid therapy: a systematic review. Dis. Colon Rectum. 2010; 53(12): 1699-1707. doi: 10.1007/DCR.0b013e3181f5643c.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Poncet G, et al. Natural history of acute colonic diverticular bleeding: a prospective study in 133 consecutive patients. Aliment. Pharmacol. Ther. 2010; 32(3): 466-471. doi: 10.1111/j.1365-2036.2010.04362.x.</mixed-citation><mixed-citation xml:lang="en">Poncet G, et al. Natural history of acute colonic diverticular bleeding: a prospective study in 133 consecutive patients. Aliment. Pharmacol. Ther. 2010; 32(3): 466-471. doi: 10.1111/j.1365-2036.2010.04362.x.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Käser SA, et al. Diagnostic value of inflammation markers in predicting perforation in acute sigmoid diverticulitis. World J. Surg. 2010; 34(11): 2717-2722. doi: 10.1007/s00268-010-0726-7.</mixed-citation><mixed-citation xml:lang="en">Käser SA, et al. Diagnostic value of inflammation markers in predicting perforation in acute sigmoid diverticulitis. World J. Surg. 2010; 34(11): 2717-2722. doi: 10.1007/s00268-010-0726-7.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Suhardja TS, Norhadi S, Seah EZ, Rodgers-Wilson S. Is early colonoscopy after CT-diagnosed diverticulitis still necessary? International Journal of Colorectal Disease. 2017; 32(4): 485-489. doi: 10.1007/s00384-016-2749-5.</mixed-citation><mixed-citation xml:lang="en">Suhardja TS, Norhadi S, Seah EZ, Rodgers-Wilson S. Is early colonoscopy after CT-diagnosed diverticulitis still necessary? International Journal of Colorectal Disease. 2017; 32(4): 485-489. doi: 10.1007/s00384-016-2749-5.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Sallinen V, Mentula P, Leppäniemi A. Risk of colon cancer after computed tomography-diagnosed acute diverticulitis: is routine colonoscopy necessary? Surgical Endoscopy. 2014; 28(3): 961-966. doi: 10.1007/s00464-013-3257-0.</mixed-citation><mixed-citation xml:lang="en">Sallinen V, Mentula P, Leppäniemi A. Risk of colon cancer after computed tomography-diagnosed acute diverticulitis: is routine colonoscopy necessary? Surgical Endoscopy. 2014; 28(3): 961-966. doi: 10.1007/s00464-013-3257-0.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Chintapalli KN, Chopra S, Ghiatas AA, et al. Diverticulitis versus colon cancer: differentiation with helical CT findings. Radiology. 1999; 210(2): 429-435. doi: 10.1148/radiology.210.2.r99fe48429.</mixed-citation><mixed-citation xml:lang="en">Chintapalli KN, Chopra S, Ghiatas AA, et al. Diverticulitis versus colon cancer: differentiation with helical CT findings. Radiology. 1999; 210(2): 429-435. doi: 10.1148/radiology.210.2.r99fe48429.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma PV, Eglinton T, Hider P, Frizelle F. Systematic review and metaanalysis of the role of routine colonic evaluation after radiologically confirmed acute diverticulitis. Annals of Surgery. 2014; 259(2): 263-272. doi: 10.1097/SLA.0000000000000294.</mixed-citation><mixed-citation xml:lang="en">Sharma PV, Eglinton T, Hider P, Frizelle F. Systematic review and metaanalysis of the role of routine colonic evaluation after radiologically confirmed acute diverticulitis. Annals of Surgery. 2014; 259(2): 263-272. doi: 10.1097/SLA.0000000000000294.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Meyer J, Orci LA, Combescure C, Balaphas A, Morel P, Buchs NC, Ris F. Risk of colorectal cancer in patients with acute diverticulitis: a systematic review and meta-analysis of observational studies. Clinical Gastroenterology and Hepatology. 2019; 17(8): 1448-1456.e17. doi: 10.1016/ j.cgh.2018.07.031.</mixed-citation><mixed-citation xml:lang="en">Meyer J, Orci LA, Combescure C, Balaphas A, Morel P, Buchs NC, Ris F. Risk of colorectal cancer in patients with acute diverticulitis: a systematic review and meta-analysis of observational studies. Clinical Gastroenterology and Hepatology. 2019; 17(8): 1448-1456.e17. doi: 10.1016/ j.cgh.2018.07.031.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Commane DM, Arasaradnam RP, Mills S, Mathers JC, Bradburn M. Diet, ageing and genetic factors in the pathogenesis of diverticular disease. World Journal of Gastroenterology. 2009; 15(20): 2479-2488. doi: 10.3748/wjg.15.2479.</mixed-citation><mixed-citation xml:lang="en">Commane DM, Arasaradnam RP, Mills S, Mathers JC, Bradburn M. Diet, ageing and genetic factors in the pathogenesis of diverticular disease. World Journal of Gastroenterology. 2009; 15(20): 2479-2488. doi: 10.3748/wjg.15.2479.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Laméris W, van Randen A, Bipat S, Bossuyt PM, Boermeester MA, Stoker J. Graded compression ultrasonography and computed tomography in acute colonic diverticulitis: meta-analysis of test accuracy. European Radiology. 2008; 18(11): 2498-2511. doi: 10.1007/s00330-008-1018-6 22.</mixed-citation><mixed-citation xml:lang="en">Laméris W, van Randen A, Bipat S, Bossuyt PM, Boermeester MA, Stoker J. Graded compression ultrasonography and computed tomography in acute colonic diverticulitis: meta-analysis of test accuracy. European Radiology. 2008; 18(11): 2498-2511. doi: 10.1007/s00330-008-1018-6 22.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Sakhnini E, Lahat A, Melzer E, Apter S, Simon C, Natour M, Bardan E, Bar-Meir S. Early colonoscopy in patients with acute diverticulitis: results of a prospective pilot study. Endoscopy. 2004; 36(6): 504-507. doi: 10.1055/s-2004-814398.</mixed-citation><mixed-citation xml:lang="en">Sakhnini E, Lahat A, Melzer E, Apter S, Simon C, Natour M, Bardan E, Bar-Meir S. Early colonoscopy in patients with acute diverticulitis: results of a prospective pilot study. Endoscopy. 2004; 36(6): 504-507. doi: 10.1055/s-2004-814398.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Morini S, Zullo A, Hassan C, Tomao S, Campo SM. Diverticulosis and colorectal cancer: between lights and shadows. Journal of Clinical Gastroenterology. 2008; 42(7): 763-770. doi: 10.1097/MCG.0b013e31816200fb.</mixed-citation><mixed-citation xml:lang="en">Morini S, Zullo A, Hassan C, Tomao S, Campo SM. Diverticulosis and colorectal cancer: between lights and shadows. Journal of Clinical Gastroenterology. 2008; 42(7): 763-770. doi: 10.1097/MCG.0b013e31816200fb.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Левчук А.Л., Абдуллаев А.Э. Радикальные хирургические вмешательства после миниинвазивных санирующих операций по поводу осложненного дивертикулита толстой кишки // Вестник НМХЦ им. Н.И.Пирогова. – 2023. – Т.18. – №3. – С.71-79. doi: 10.25881/20728255_2023_18_3_71.</mixed-citation><mixed-citation xml:lang="en">Levchuk AL, Abdullaev AE. Radical surgical interventions after minimally invasive sanitizing operations for complicated diverticulitis of the colon. Bulletin of Pirogov National Medical &amp; Surgical Center. 2023; 18(3): 71-79 (In Russ.) doi: 10.25881/20728255_2023_18_3_71.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Левчук А.Л., Абдуллаев А.Э. Диагностика острого дивертикулита толстой кишки и его осложнений в хирургической практике // Вестник НМХЦ им. Н.И. Пирогова. – 2021. – Т.16. – №3. – С.25-32. doi: 10.25881/20728255_2021_ 16_3_25.</mixed-citation><mixed-citation xml:lang="en">Levchuk AL, Abdullaev AE. Diagnosis of acute diverticulitis of the colon and its complications in surgical practice. Bulletin of Pirogov National Medical &amp; Surgical Center. 2021; 16(3): 25-32. (In Russ.) doi: 10.25881/20728255_2021_ 16_3_25.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Карасев И.А., Малихова О.А., Давыдкина Т.С. Роль кишечной микробиоты в патогенезе колоректальногорака. Обзор литературных данных // Злокачественные опухоли. – 2020. – №3. – С.60-62. doi: 10.18027/2224-5057-2020-10-3s1-60-62.</mixed-citation><mixed-citation xml:lang="en">Karasev IA, Melikhova OA, Davydkina TS. The role of the intestinal microbiota in the pathogenesis of colorectal cancer. Review of the literature data. Malignant tumors. 2020; 3: 60-62. (In Russ.) doi: 10.18027/2224-5057-2020-10-3s1-60-62.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Morgan E, Arnold M, Gini A, et al Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN Gut Published Online First: 08 September 2022. doi: 10.1136/gutjnl-2022-327736.</mixed-citation><mixed-citation xml:lang="en">Morgan E, Arnold M, Gini A, et al Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN Gut Published Online First: 08 September 2022. doi: 10.1136/gutjnl-2022-327736.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
