<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pirogovestnik</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Национального медико-хирургического центра им. Н.И. Пирогова</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Pirogov National Medical &amp; Surgical Center</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-8255</issn><issn pub-type="epub">2782-3628</issn><publisher><publisher-name>Национальный медико-хирургический Центр им. Н.И. Пирогова</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25881/20728255_2024_19_3_33</article-id><article-id custom-type="elpub" pub-id-type="custom">pirogovestnik-144</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ВЛИЯНИЕ СЕРДЕЧНО-СОСУДИСТО-ПОЧЕЧНО-МЕТАБОЛИЧЕСКОГО СИНДРОМА И ОТДЕЛЬНО КАРДИОРЕНАЛЬНОГО НА ТЕЧЕНИЕ ИБС</article-title><trans-title-group xml:lang="en"><trans-title>THE INFLUENCE OF CARDIOVASCULAR – RENAL – METABOLIC SYNDROME AND SEPARATELY CARDIORENAL SYNDROME ON THE COURSE OF CORONARY HEART DISEASE</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хабчабов</surname><given-names>Р. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Khabchabov</surname><given-names>R. G.</given-names></name></name-alternatives><email xlink:type="simple">rustam033@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Махмудова</surname><given-names>Э. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Makhmudova</surname><given-names>E. R.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдуллаев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdullaev</surname><given-names>A. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гафурова</surname><given-names>Р. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gafurova</surname><given-names>R. M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исламова</surname><given-names>У. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Islamova</surname><given-names>U. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джанбулатов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhanbulatov</surname><given-names>M. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анатова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Anatova</surname><given-names>A. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Дагестанский государственный медицинский университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dagestan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>23</day><month>10</month><year>2024</year></pub-date><volume>19</volume><issue>3</issue><fpage>33</fpage><lpage>37</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хабчабов Р.Г., Махмудова Э.Р., Абдуллаев А.А., Гафурова Р.М., Исламова У.А., Джанбулатов М.А., Анатова А.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Хабчабов Р.Г., Махмудова Э.Р., Абдуллаев А.А., Гафурова Р.М., Исламова У.А., Джанбулатов М.А., Анатова А.А.</copyright-holder><copyright-holder xml:lang="en">Khabchabov R.G., Makhmudova E.R., Abdullaev A.A., Gafurova R.M., Islamova U.A., Dzhanbulatov M.A., Anatova A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://submit.pirogov-vestnik.ru/jour/article/view/144">https://submit.pirogov-vestnik.ru/jour/article/view/144</self-uri><abstract><p>Цель. Выявить различия сердечно-сосудисто-почечно-метаболического синдрома и отдельно кардиоренального на течение ИБС. Методика. В исследование включены 111 пациентов – 71 (59,5%) мужчины и 40 (40,5%) женщин, которые проходили лечение в больнице РКБ СМП №2, с 2022 по 2023 г. Пациенты были разделены на две группы, в 1-ю группу вошли n = 52 с сердечно-сосудисто-почечно-метаболическим синдромом, во 2-ю группу вошли n = 59 с кардиоренальным синдромом. Продолжительность исследования – 18 месяцев. Статистическая обработка полученных данных проводилась с использованием программ Excel и Statistica 7.0.Результаты. Первичные показатели ХС ЛПНП в 1-й группе составляли 2,9±3,6 во 2-й группе 2,2±3,7 (p = 0,08), а при повторном обследовании, соотношение значений было следующим – 3,2±2,8 к 32,7±3,9 (p = 0,06). Отмечался рост общего холестерина и триглицеридов, а показатели хорошего ХС ЛПВП, практически не изменились p&lt;0,05. Пациентов с сахарным диабетом 2 степени, к концу обследования увеличилось в обеих группах, но не столь значимо по отношению к общей массе 2,7% к 1,8%, p = 0,01. При повторном обследовании превалировали показатели артериальной гипертензии 2 степени в группе с сердечно-сосудисто-почечно-метаболическим синдром, соотношение 34,6 к 23,7 p = 0,01. Но, как и при поступлении, так и при повторном обследовании, рост артериальной гипертензии 3 степени, превышал у пациентов с кардиоренальным синдромом 25,0 к 27,1 p = 0,04. Развитие острого инфаркта миокарда, преобладало в группе с сердечно-сосудисто-почечно-метаболическим синдром, как и количество повторных событий ИБС, соотношение 33,6 к 23,4 p = 0,05.Заключение. В проведенном нами исследовании показано, что пациенты с сердечно-сосудисто-почечно-метаболическим синдромом быстрее госпитализируются и у них чаще рецидивирует ИБС. Что касается смертельных случаев, то они оказались равными у пациентов с сердечно-сосудисто-почечно-метаболическим и кардиоренальным синдромом</p></abstract><trans-abstract xml:lang="en"><p>Objective. To identify differences between the cardiovascular – renal – metabolic syndrome and separately cardiorenal syndrome on the course of coronary heart disease.Methods. The study included 111 patients – 71 (59.5%) men and 40 (40.5%)women who were treated at the RCH Hospital No. 2 from 2022 to 2023. The patients were divided into two groups, group 1 included n = 52 with cardiovascular – renal – metabolic syndrome, group 2 included n = 59 with cardiorenal syndrome. The duration of the study is 18 months. Statistical processing of the obtained data was carried out using Excel and Statistica 7.0 programs.Results. Thus, the primary indicators of LDL cholesterol in the 1st group were 2.9±3.6, in the 2nd group 2.2±3.7 (p = 0.08), and upon re – examination, the ratio of values was as follows – 3 .2±2.8 to 32.7±3.9 (p = 0.06). There was an increase in total cholesterol and triglycerides, and indicators of good HDL cholesterol remained virtually unchanged p&lt;0.05. Patients with stage 2 diabetes mellitus increased by the end of the examination in both groups, but so significantly in relation to the total weight of 2.7% to 1.8%, p = 0.01. During the repeated examination, the indicators of arterial hypertension of the 2nd degree prevailed in the group with cardiovascular – renal – metabolic syndrome 34.6 to 23.7 p = 0.01. But, both upon admission and during re – examination, the increase in arterial hypertension of the 3rd degree exceeded in patients with cardiorenal syndrome 25.0 to 27.1 p = 0.04. The development of acute myocardial infarction predominated in the group with cardiovascular – renal – metabolic syndrome, and the number of repeated events of coronary heart disease, the ratio was 33.6 to 23.4 p = 0.05.Conclusion. Our study showed that patients with cardiovascular – renal – metabolic syndrome are hospitalized faster and have recurrent development of coronary heart disease. As for deaths, they were equal in patients with cardiovascular – renal – metabolic and cardiorenal syndrome</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудисто-почечно-метаболический синдромом</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>кардиоренальный синдром</kwd><kwd>сахарный диабета 2 типа</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular – renal – metabolic syndrome</kwd><kwd>coronary heart disease</kwd><kwd>cardiorenal syndrome</kwd><kwd>type 2 diabetes mellitus</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kuschnir MCC, Bloch KV, Szklo M, et al. ERICA: prevalence of metabolic syndrome in Brazilian adolescents. Journal of Revista de saúde Pública. 2016; 50(11): 256-268.</mixed-citation><mixed-citation xml:lang="en">Kuschnir MCC, Bloch KV, Szklo M, et al. ERICA: prevalence of metabolic syndrome in Brazilian adolescents. Journal of Revista de saúde Pública. 2016; 50(11): 256-268.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Xiang Y, Zhou W, Duan X, et al. Metabolic Syndrome, and Particularly the Hypertriglyceridemic-Waist Phenotype, Increases Breast Cancer Risk, and Adiponectin Is a Potential Mechanism: A Case-Control Study in Chinese Women. Circulation. AHA/ASA Journals. 2020; 10(16): 905-927</mixed-citation><mixed-citation xml:lang="en">Xiang Y, Zhou W, Duan X, et al. Metabolic Syndrome, and Particularly the Hypertriglyceridemic-Waist Phenotype, Increases Breast Cancer Risk, and Adiponectin Is a Potential Mechanism: A Case-Control Study in Chinese Women. Circulation. AHA/ASA Journals. 2020; 10(16): 905-927</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ivanova N, Liu Q, Agca C, et al. White matter inflammation and cognitive function in a co-morbid metabolic syndrome and prodromal Alzheimer’s disease rat model. Journal of Neuroinflammation. 2020; 17(1): 29-53.</mixed-citation><mixed-citation xml:lang="en">Ivanova N, Liu Q, Agca C, et al. White matter inflammation and cognitive function in a co-morbid metabolic syndrome and prodromal Alzheimer’s disease rat model. Journal of Neuroinflammation. 2020; 17(1): 29-53.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Grgurevic I, Podrug K, Mikolasevic I, et al. Natural History of Nonalcoholic Fatty Liver Disease: Implications for Clinical Practice and an Individualized Approach. Canadian Journal of Gastroenterology and Hepatology. 2020; 20(1): 14-30.</mixed-citation><mixed-citation xml:lang="en">Grgurevic I, Podrug K, Mikolasevic I, et al. Natural History of Nonalcoholic Fatty Liver Disease: Implications for Clinical Practice and an Individualized Approach. Canadian Journal of Gastroenterology and Hepatology. 2020; 20(1): 14-30.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Takashi K, Hiroshi M, Hirotaka W, Daisuke Y, Koichi N, et al. Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan. Journal Diabetes, Obesity and Metabolism. 2022; 24(6): 2283-2296.</mixed-citation><mixed-citation xml:lang="en">Takashi K, Hiroshi M, Hirotaka W, Daisuke Y, Koichi N, et al. Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan. Journal Diabetes, Obesity and Metabolism. 2022; 24(6): 2283-2296.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ndumele CE, Neeland IJ, Tuttle KR, Chow SL, et al. A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: a scientific statement from the American Heart Association. Circulation. AHA/ASA Journals. 2023; 1(48): 1636-1664.</mixed-citation><mixed-citation xml:lang="en">Ndumele CE, Neeland IJ, Tuttle KR, Chow SL, et al. A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: a scientific statement from the American Heart Association. Circulation. AHA/ASA Journals. 2023; 1(48): 1636-1664.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rangaswami J, Bhalla V, Blair JEA, et al. Cardiorenal syndrome: classification, pathophysiology, diagnosis, and treatment strategies: a scientific statement from the American Heart Association. Circulation. AHA/ASA Journals. 2019; 13(9): 840-878.</mixed-citation><mixed-citation xml:lang="en">Rangaswami J, Bhalla V, Blair JEA, et al. Cardiorenal syndrome: classification, pathophysiology, diagnosis, and treatment strategies: a scientific statement from the American Heart Association. Circulation. AHA/ASA Journals. 2019; 13(9): 840-878.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Koenen M, Hill MA, Cohen P, Sowers JR. Obesity, adipose tissue and vascular dysfunction. Circulation Research. AHA/ASA Journals. 2021; 12(8): 951-968.</mixed-citation><mixed-citation xml:lang="en">Koenen M, Hill MA, Cohen P, Sowers JR. Obesity, adipose tissue and vascular dysfunction. Circulation Research. AHA/ASA Journals. 2021; 12(8): 951-968.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Khayyat-Kholghi M, Oparil S, Davis BR, Tereshchenko LG. Worsening kidney function is the major mechanism of heart failure in hypertension: the ALLHAT study. Contribution to journal. 2021; 9(11): 100-111.</mixed-citation><mixed-citation xml:lang="en">Khayyat-Kholghi M, Oparil S, Davis BR, Tereshchenko LG. Worsening kidney function is the major mechanism of heart failure in hypertension: the ALLHAT study. Contribution to journal. 2021; 9(11): 100-111.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hicks CW, Yang C, Ndumele CE, et al. Associations of obesity with incident hospitalization related to peripheral artery disease and critical limb ischemia in the ARIC study. Journal of the American Heart Association. 2018; 7(5): 86-104.</mixed-citation><mixed-citation xml:lang="en">Hicks CW, Yang C, Ndumele CE, et al. Associations of obesity with incident hospitalization related to peripheral artery disease and critical limb ischemia in the ARIC study. Journal of the American Heart Association. 2018; 7(5): 86-104.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Powell-Wiley TM, Poirier P, Burke LE, et al. Obesity and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. AHA/ASA Journals. 2021; 14(3): 984-1010.</mixed-citation><mixed-citation xml:lang="en">Powell-Wiley TM, Poirier P, Burke LE, et al. Obesity and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. AHA/ASA Journals. 2021; 14(3): 984-1010.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lee M-K, Han K, Kim MK, et al. Changes in metabolic syndrome and its components and the risk of type 2 diabetes: a nationwide cohort study. Nature Journal Scientific reports. 2020; 10(1): 23-43.</mixed-citation><mixed-citation xml:lang="en">Lee M-K, Han K, Kim MK, et al. Changes in metabolic syndrome and its components and the risk of type 2 diabetes: a nationwide cohort study. Nature Journal Scientific reports. 2020; 10(1): 23-43.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ефремова О.А. Камышникова Л.А. Никитин Е.А. Параллели липидного обмена и гипергомоцистеинемии у больных с ИБС и метаболическим синдромом // Сетевой научно-практический журнал. Научный результат. Серия «Медицина и фармация». – 2014. – Т.1. – №1. – С.12-19.</mixed-citation><mixed-citation xml:lang="en">Efremova OA, Kamyshnikova LA. Nikitin EA. Parallels of lipid metabolism and hyperhomocysteinemia in patients with ischemic heart disease and metabolic syndrome. Network scientific and practical journal. Scientific result. Series “Medicine and Pharmacy”. 2014; 1(1): 12-19. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Кутикова О.Ю., Антонюк М.В., Гвозденко Т.А., Новгородцева Т.П. Метаболические аспекты связи астмы и ожирения // Ожирение и обмен веществ. – 2019. – T.15. – №4. – С.9-14.</mixed-citation><mixed-citation xml:lang="en">Kytikova OYu, Antonyuk MV, Gvozdenko TA, Novgorodtseva TP. Metabolic aspects of the relationship between asthma and obesity. Obesity and metabolism. 2019; 15(4): 9-14. (In Russ.).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
